An atypical antipsychotic
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Analytical Standard(s)
40162Olanzapine (CRM)
Labeled Version(s)
25447Olanzapine-d8
Metabolite(s)
33422N-desmethyl Olanzapine
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Olanzapine

Item No. 11937

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine
CAS Number
132539-06-1
Synonyms
  • LY170053
Molecular Formula
C17H20N4S
Formula Weight
312.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 16 mg/mlDMSO:PBS(pH7.2) (1:1): 0.5 mg/mlEthanol: 1 mg/ml
λmax
226, 272 nm
SMILES
CN(CC1)CCN1C2=NC3=CC=CC=C3NC4=C2C=C(C)S4
InChi Code
InChI=1S/C17H20N4S/c1-12-11-13-16(21-9-7-20(2)8-10-21)18-14-5-3-4-6-15(14)19-17(13)22-12/h3-6,11,19H,7-10H2,1-2H3
InChi Key
KVWDHTXUZHCGIO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

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    Product Description

    Olanzapine is an atypical antipsychotic that binds to dopamine D1, D2, and D4 receptors (Kis = 31, 11, and 27 nM, respectively) as well as the serotonin (5-HT) receptor subtypes 5-HT2A, 5-HT2C, and 5-HT3 (Kis = 4, 11, and 57 nM, respectively).1 It also binds to M1 muscarinic acetylcholine, α1-adrenergic, and histamine H1 receptors (Kis = 2, 19, and 7 nM, respectively). Olanzapine (0.5 mg/kg, i.p.) decreases immobility time in the forced swim test in non-stressed and prenatally-stressed rats, indicating antidepressant-like activity.2 It also decreases the number of avoidances made in the conditioned avoidance response test in rats when administered at doses of 0.5 and 1 mg/kg.3 Formulations containing olanzapine have been used in the treatment of schizophrenia and bipolar disorder.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bymaster, F.P., Calligaro, D.O., Falcone, J.F., et al. Radioreceptor binding profile of the atypical antipsychotic olanzapine. Neuropsychopharmacology 14(2), 87-96 (1996).

    2. Nowakowska, E., Kus, K., Ratajczak, P., et al. The influence of aripiprazole, olanzapine and enriched environment on depressant-like behavior, spatial memory dysfunction and hippocampal level of BDNF in prenatally stressed rats. Pharmacol. Rep. 66(3), 404-411 (2014).

    3. Ashby, D.M., Lapish, C.C., and Phillips, A.G. Stability of avoidance behaviour following repeated intermittent treatment with clozapine, olanzapine or D,L-govadine. Behav. Pharmacol. 26(1-2), 133-138 (2015).