A major metabolite of olanzapine
Related Products
Parent Compound(s)
11937Olanzapine
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

N-desmethyl Olanzapine

Item No. 33422

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-methyl-4-(1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine
CAS Number
161696-76-0
Synonyms
  • LY170055
  • 4'-N-desmethyl Olanzapine
Molecular Formula
C16H18N4S
Formula Weight
298.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:4): 0.2 mg/mlEthanol: 10 mg/ml
λmax
227, 272 nm
SMILES
CC1=CC2=C(S1)NC3=C(C=CC=C3)N=C2N4CCNCC4
InChi Code
InChI=1S/C16H18N4S/c1-11-10-12-15(20-8-6-17-7-9-20)18-13-4-2-3-5-14(13)19-16(12)21-11/h2-5,10,17,19H,6-9H2,1H3
InChi Key
FHPIXVHJEIZKJW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $36

    Add

    5 mg

    $153

    Add

    10 mg

    $219

    Add

    25 mg

    $462

    Add
    Product Description

    N-desmethyl Olanzapine is a major metabolite of the atypical antipsychotic agent olanzapine (Item No. 11937).1,2 N-desmethyl Olanzapine is formed via oxidative metabolism of olanzapine by the cytochrome 450 (CYP) isoform CYP1A2.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ring, B.J., Catlow, J., Lindsay, T.J., et al. Identification of the human cytochromes P450 responsible for the in vitro formation of the major oxidative metabolites of the antipsychotic agent olanzapine. J. Pharmacol. Exp. Ther. 276(2), 658-666 (1996).

    2. Chiu, J.A., and Franklin, R.B. Analysis and pharmacokinetics of olanzapine (LY170053) and two metabolites in rat plasma using reversed-phase HPLC with electrochemical detection. J. Pharm. Biomed. Anal. 14(5), 609-615 (1996).