A CXCR4 receptor antagonist
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AMD 3465 (hydrobromide)

Item No. 11959

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[[4-(1,4,8,11-tetraazacyclotetradec-1-ylmethyl)phenyl]methyl]-2-pyridinemethanamine, hexahydrobromide
CAS Number
185991-07-5
Molecular Formula
C24H38N6 • 6HBr
Formula Weight
896.1
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2.5 mg/mlDMSO: 3 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
203, 259 nm
SMILES
N1(CC2=CC=C(CNCC3=NC=CC=C3)C=C2)CCNCCCNCCNCCC1
InChi Code
InChI=1S/C24H38N6/c1-2-13-29-24(5-1)20-28-19-22-6-8-23(9-7-22)21-30-17-4-12-26-15-14-25-10-3-11-27-16-18-30/h1-2,5-9,13,25-28H,3-4,10-12,14-21H2
InChi Key
CWJJHESJXJQCJA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    5 mg

    $106

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    10 mg

    $201

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    25 mg

    $444

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    Cayman Chemical
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    Product Description

    AMD 3465 blocks the cell surface binding of CXCL12 with an IC50 value of 18 nM.1 It inhibits CXCL12-induced calcium mobilization (IC50 = 4 nM) and at 6,250 nM completely blocks CXCL12-induced chemotaxis of SupT1 cells.1 AMD 3465 is active against various HIV strains with IC50 values ranging from 6 to 12 nM.1 It dose dependently inhibits eosinophil recruitment during type-2 granuloma formation and interferes with primary and secondary T-cell activation events in lymphoid tissue.2 At 50 μg/day, AMD 3465 blocks tumor growth and prevents CXCL12-induced cAMP suppression in xenograft models of medulloblastoma and glioblastoma.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hatse, S., Princen, K., De Clercq, E., et al. AMD3465, a monomacrocyclic CXCR4 antagonist and potent HIV entry inhibitor. Biochem. Pharmacol. 70, 752-761 (2005).

    2. Hu, J.S., Freeman, C.M., Stolberg, V.R., et al. AMD3465, a novel CXCR4 receptor antagonist, abrogates schistosomal antigen-elicited (type-2) pulmonary granuloma formation. Am. J. Pathol. 169(2), 424-432 (2006).

    3. Yang, L., Jackson, E., Woerner, B.M., et al. Blocking CXCR4-mediated cyclic AMP suppression inhibits brain tumor growth in vivo. Cancer Res. 67(2), 651-658 (2007).