A GABAB presynaptic receptor antagonist
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CGP 36216 (hydrochloride)

Item No. 11985

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
p-(3-aminopropyl)-p-ethyl-phosphinic acid, monohydrochloride
CAS Number
1781834-71-6
Molecular Formula
C5H14NO2P • HCl
Formula Weight
187.6
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 0.25 mg/mlDMSO: 20 mg/mlEthanol: 5 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
O=P(CC)(CCCN)O.Cl
InChi Code
InChI=1S/C5H14NO2P.ClH/c1-2-9(7,8)5-3-4-6;/h2-6H2,1H3,(H,7,8);1H
InChi Key
CFQFXUJBWMPODB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $40

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    5 mg

    $129

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    10 mg

    $237

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    Product Description

    CGP 36216 is a selective antagonist of GABAB receptors (IC50 = 43 µM).1,2 Its action is reversed by the GABAB receptor agonist baclofen.2 It is active at presynaptic, but not postsynaptic, receptors.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Froestl, W., Mickel, S.J., von Sprecher, G., et al. Phosphinic acid analogues of GABA. 2. Selective, orally active GABAB antagonists. J. Med. Chem. 38(17), 3313-3331 (1995).

    2. Ong, J., Bexis, S., Marino, V., et al. CGP 36216 is a selective antagonist at GABAB presynaptic receptors in rat brain. Eur. J. Pharmacol. 415, 191-195 (2001).