A negative allosteric modulator of the mGlu5 receptor
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VU0360223

Item No. 11995

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-fluoro-5-(2-methyl-5-benzothiazolyl)-benzonitrile
CAS Number
1274859-33-4
Synonyms
  • CAY10651
Molecular Formula
C15H9FN2S
Formula Weight
268.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 16 mg/mlDMF:PBS(pH7.2) (1:2): 0.33 mg/mlDMSO: 10 mg/ml
λmax
235 nm
SMILES
FC1=CC(C#N)=CC(C2=CC3=C(SC(C)=N3)C=C2)=C1
InChi Code
InChI=1S/C15H9FN2S/c1-9-18-14-7-11(2-3-15(14)19-9)12-4-10(8-17)5-13(16)6-12/h2-7H,1H3
InChi Key
WDHYUBIJZHYUOV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $103

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    10 mg

    $143

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    50 mg

    $569

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    Product Description

    VU0360223 is a noncompetitive antagonist (negative allosteric modulator) of mGlu5 that demonstrates an IC50 value of 61 nM in a calcium mobilization assay and a Ki value of 477 nM in a radioligand binding assay.1 A 10 μM concentration of VU0360223 results in a near complete blockade of the glutamate response in cortical astrocytes.1 A 30 mg/kg dose of VU0360223 in mice yields potent inhibition in a marble burying model of anxiety and is efficacious in an operant sensation seeking model of addiction.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lindsley, C.W., Bates, B.S., Menon, U.N., et al. (3-Cyano-5-fluorophenyl)biaryl negative allosteric modulators of mGlu5: Discovery of a new tool compound with activity in the OSS mouse model of addiction. ACS Chem. Neurosci. 2, 471-482 (2011).