An HNF4α antagonist
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CAY10803

Item No. 12032

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-methyl-1-[(2-methyl-4-nitrophenyl)sulfonyl]-1H-benzimidazole
Molecular Formula
C15H13N3O4S
Formula Weight
331.3
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 16 mg/mlDMSO: 14 mg/mlDMSO:PBS (pH 7.2) (1:10): 0.09 mg/ml
λmax
245 nm
SMILES
CC1=NC2=CC=CC=C2N1S(C3=C(C)C=C(C=C3)[N+]([O-])=O)(=O)=O
InChi Code
InChI=1S/C15H13N3O4S/c1-10-9-12(18(19)20)7-8-15(10)23(21,22)17-11(2)16-13-5-3-4-6-14(13)17/h3-9H,1-2H3
InChi Key
DFIUIVQPFLAYNK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $53

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    10 mg

    $95

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    25 mg

    $212

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    50 mg

    $396

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Hepatocyte nuclear factor 4α (HNF4α) is a nuclear receptor transcription factor that controls the expression of many genes including those involved in glucose and lipid homeostasis and maintenance of epithelial differentiation. CAY10803 is a small molecule antagonist of HNF4α that has been shown to repress the expression of known HNF4α target genes.1 At concentrations up to 20 μM, CAY10803 has been shown to reduce endogenous insulin gene expression by as much as 50-fold in T6PNE cells.1 The hepatocytes from livers of mice injected with 10 and 30 mg/kg BI-6015 exhibit marked, dose-dependent fat accumulation (steatosis).1 Additionally, at a daily dose of 30 mg/kg, CAY10803 induces apoptosis in a human hepatocellular carcinoma mouse model.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kiselyuk, A., Lee, S.H., Farber-Katz, S., et al. HNF4α antagonists discovered by a high-throughput screen for modulators of the human insulin promoter. Chem. Biol. 19(7), 806-818 (2012).