For immunochemical detection of CysLT2
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CysLT2 Receptor (C-Term) Polyclonal Antibody

Item No. 120550

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Cysteinyl-Leukotriene Receptor 2
Immunogen
Synthetic peptide from the C-terminal region of human CysLT2 Receptor
Formulation (Request formulation change)
Peptide affinity-purified polyclonal antibody
Storage Buffer
PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide
Host
Rabbit
Applications
ELISA, FC, IHC, and WB
Cross Reactivity
(-) CysLT1 receptor
Species Reactivity
(+) Human CysLT2 receptor(-) Mouse CysLT2 receptor(-) Ovine CysLT2 receptor(-) Rat CysLT2 receptor
UniProt Accession №
Q9NS75
Origin
Animal/Rabbit
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    The cysteinyl leukotrienes (cysLTs; LTC4, LTD4, and LTE4) contract airway and pulmonary vascular smooth muscle, increase vascular permeability, and stimulate mucus secretion, thereby playing a major role in asthma.1,2,3,4 LTC4, LTD4, and LTE4 mediate their actions via at least two receptors designated CysLT1 and CysLT2.1 Cloning of the human CysLT2 receptor reveals it is a 346 amino acid protein with 38% homology to the CysLT1 receptor.5,6 The rank order of binding for leukotrienes to the cloned receptor, as determined using a radioligand binding assay, is LTC4 = LTD4 >> LTE4.5 The mRNA for the human CysLT2 receptor is expressed in lung macrophages, airway smooth muscle, cardiac Purkinje cells, adrenal medulla cells, peripheral blood leukocytes, spleen, placenta, and brain.5,7

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gorenne, I., Norel, X., and Brink, C. Cysteinyl leukotriene receptors in the human lung: What’s new? Trends Pharmacol. Sci. 17(10), 342-343 (1996).

    2. Dahlén, S.E., Hansson, G., Hedqvist, P., et al. Allergen challenge of lung tissue from asthmatics elicits bronchial contraction that correlates with the release of leukotrienes C4, D4, and E4. Proc. Natl. Acad. Sci. USA 80(6), 1712-1716 (1983).

    3. Busse, W.W. The role of leukotrienes in asthma and allergic rhinitis. Clin. Exp. Allergy 26(8), 868-879 (1996).

    4. Hedqvist, P., Dahlén, S.E., Gustafsson, L., et al. Biological profile of leukotrienes C4 and D4. Acta Physiol. Scand. 110(3), 331-333 (1980).

    5. Heise, C.E., O'Dowd, B.F., Figueroa, D.J., et al. Characterization of the human cysteinyl leukotriene 2 receptor. The Journal of Biological Chemisty 275(39), 30531-30536 (2000).

    6. Lynch, K.R., O'Neill, G.P., Liu, Q., et al. Characterization of the human cysteinyl leukotriene CysLT1 receptor. Nature 399(6738), 789-793 (1999).

    7. Takasaki, J., Kamohara, M., Matsumoto, M., et al. The molecular characterization and tissue distribution of the human cysteinyl leukotriene CysLT2 receptor. Biochem. Biophys. Res. Commun. 274, 316-322 (2000).