For immunochemical detection of the CysLT2 receptor
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CysLT2 Receptor (N-Term) Polyclonal Antibody

Item No. 120560

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Cysteinyl-Leukotriene Receptor 2
  • CysLTR2
Immunogen
Peptide corresponding to the N-terminal region of human CysLT2
Formulation (Request formulation change)
Peptide affinity-purified antibody
Storage Buffer
TBS, pH 7.4, when reconstituted in 500 µl double distilled water
Host
Rabbit
Applications
ELISA, FC, and WB
Cross Reactivity
(+) CysLT2(-) CysLT1
Species Reactivity
(+) Human(-) Rat
UniProt Accession №
Q9NS75
Origin
Animal/Rabbit
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    Cysteinyl leukotriene receptor 2 (CysLT2) is a G protein-coupled receptor that mediates the actions of leukotriene C4 (LTC4), LTD4, and, to a lesser extent, LTE4.1 It is expressed primarily in the heart, placenta, spleen, lymph nodes, and peripheral blood leukocytes.1,2 Signaling induced by LTC4 through the CysLT2 receptor induces the production of chemokines via NF-κB and AP-1 activation in endothelial cells, indicating a role in inflammation.3 A CysLT2 receptor containing a leucine-to-glutamine substitution at position 129 (L129Q) has been found in human uveal melanoma cells and is associated with tumorigenesis in vivo.4,5 SNPs in CYSLTR2 are associated with aspirin intolerance in patients with asthma.6 Cayman’s CysLT2 Receptor (N-Term) Polyclonal Antibody can be used for ELISA, flow cytometry (FC), and Western blot (WB) applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Heise, C.E., O'Dowd, B.F., Figueroa, D.J., et al. Characterization of the human cysteinyl leukotriene 2 receptor. The Journal of Biological Chemisty 275(39), 30531-30536 (2000).

    2. Takasaki, J., Kamohara, M., Matsumoto, M., et al. The molecular characterization and tissue distribution of the human cysteinyl leukotriene CysLT2 receptor. Biochem. Biophys. Res. Commun. 274, 316-322 (2000).

    3. Thompson, C., Cloutier, A., Bossé, Y., et al. Signaling by the cysteinyl-leukotriene receptor 2. Involvement in chemokine gene transcription. The Journal of Biological Chemisty 283(4), 1974-1984 (2008).

    4. Moore, A.R., Ceraudo, E., Sher, J.J., et al. Recurrent activating mutations of G-protein-coupled receptor CYSLTR2 in uveal melanoma. Nat. Genet. 48(6), 675-680 (2016).

    5. Ceraudo, E., Horioka, M., Mattheisen, J.M., et al. Direct evidence that the GPCR CysLTR2 mutant causative of uveal melanoma is constitutively active with highly biased signaling. The Journal of Biological Chemisty 296, 100163 (2021).

    6. Park, J.S., Chang, H.S., Park, C.-S., et al. Association analysis of cysteinyl-leukotriene receptor 2 (CYSLTR2) polymorphisms with aspirin intolerance in asthmatics. Pharmacogenet. Genomics 15(7), 483-492 (2005).