A DP receptor antagonist
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BW A868C

Item No. 12060

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[(2-cyclohexyl-2-hydroxyethyl)amino]-2,5-dioxo-1-(phenylmethyl)-4-imidazolidineheptanoic acid
CAS Number
118675-50-6
Molecular Formula
C25H37N3O5
Formula Weight
459.6
Purity
≥98%
Formulation
A 10 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 20 mg/mlEthanol: 50 mg/mlPBS (pH 7.2): 250 µg/ml
SMILES
O=C1C(CCCCCCC(O)=O)N(NCC(O)C2CCCCC2)C(N1CC3=CC=CC=C3)=O
InChi Code
InChI=1S/C25H37N3O5/c29-22(20-13-7-4-8-14-20)17-26-28-21(15-9-1-2-10-16-23(30)31)24(32)27(25(28)33)18-19-11-5-3-6-12-19/h3,5-6,11-12,20-22,26,29H,1-2,4,7-10,13-18H2,(H,30,31)
InChi Key
YZJVWSKJHGEIBL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $96

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    5 mg

    $423

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    10 mg

    $748

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    Product Description

    BW A868C is a hydantoin compound that is structurally related to the DP receptor agonist BW 245C.1,2 BW A868C antagonizes the prostaglandin D2 and BW 245C-induced activation of human platelet adenylate cyclase. It reverses the anti-aggregatory effects of DP receptor agonists in a dose-dependent manner. Likewise, BW A868C antagonizes the accumulation of cAMP in rabbit non-pigmented ciliary epithelial cells.3 It has virtually no effect on human TP, IP, EP1, EP2, and FP receptors. The Ki for BW A868C is approximately 1.7 nM.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Caldwell, A.G., Harris, C.J., Stepney, R., et al. Hydantoin prostaglandin analogues, potent and selective inhibitors of platelet aggregation. J. Chem. Soc. Chem. Comm. 561-562 (1979).

    2. Trist, D.G., Collins, B.A., Wood, J., et al. The antagonism by BW A868C of PGD2 and BW245C activation of human platelet adenylate cyclase. Br. J. Pharmacol. 96(2), 301-306 (1989).

    3. Bhattacherjee, P., Jacobs, N., Coca-Prados, M., et al. Identification of prostanoid receptors in rabbit non-pigmented ciliary epithelial cells. Exp. Eye Res. 62(5), 491-498 (1996).

    4. Giles, H., Leff, P., Bolofo, M.L., et al. The classification of prostaglandin DP-receptors in platelets and vasculature using BW A868C, a novel, selective and potent competitive antagonist. Br. J. Pharmacol. 96(2), 291-300 (1989).