A selective inverse agonist of RORα
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SR 3335

Item No. 12072

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-2-thiophenesulfonamide
CAS Number
293753-05-6
Synonyms
  • ML 176
Molecular Formula
C13H9F6NO3S2
Formula Weight
405.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 16 mg/mlEthanol: 33 mg/mlEthanol:PBS (pH 7.2) (1:1): 0.5 mg/ml
λmax
231 nm
SMILES
OC(C(F)(F)F)(C(F)(F)F)C1=CC=C(NS(C2=CC=CS2)(=O)=O)C=C1
InChi Code
InChI=1S/C13H9F6NO3S2/c14-12(15,16)11(21,13(17,18)19)8-3-5-9(6-4-8)20-25(22,23)10-2-1-7-24-10/h1-7,20-21H
InChi Key
LZWUNZRMANFRAO-UHFFFAOYSA-N
License
Sold under license from The Scripps Research Institute.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $117

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    10 mg

    $205

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    25 mg

    $445

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    Product Description

    SR 3335 is a selective inverse agonist of retinoic acid receptor-related orphan receptor α (RORα), competitively inhibiting the binding of 25-hydroxycholesterol to the ligand binding domain (Ki = 220 nM) and inhibiting constitutive transactivation activity (IC50 = 480 nM).1 It is without effect on RORβ, RORγ, farnesoid X receptor, or liver X receptor α. SR 3335 evokes RORα-dependent effects both in vitro and in vivo, altering gene expression as well as gluconeogenesis.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kumar, N., Kojetin, D.J., Solt, L.A., et al. Identification of SR3335 (ML176): A synthetic RORα selective inverse agonist. ACS Chem. Biol. 6(3), 218-222 (2011).