A synthetic SOD mimetic
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EUK 124

Item No. 12500

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(SP-5-13)-chloro[[2,2’-[1,2-ethanediylbis[(nitrilo-κN)methylidyne]]bis[3,5-dimethoxyphenolato-κO]](2-)]-manganese
CAS Number
186299-35-4
Molecular Formula
C20H22ClMnN2O6
Formula Weight
476.8
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 20 mg/mlEthanol: 1 mg/mlPBS (pH 7.2): 0.2 mg/ml
λmax
223, 243, 303, 347 nm
SMILES
[Cl-][Mn+3]([N]1=CC2=C3OC)([O-]C2=CC(OC)=C3)([O-]C4=CC(OC)=C5)[N](CC1)=CC4=C5OC
InChi Code
InChI=1S/C20H24N2O6.ClH.Mn/c1-25-13-7-17(23)15(19(9-13)27-3)11-21-5-6-22-12-16-18(24)8-14(26-2)10-20(16)28-4;;/h7-12,23-24H,5-6H2,1-4H3;1H;/q;;+3/p-3/b21-11+,22-12+;;
InChi Key
CZWTULNLOQLTRE-AIMLMLFYSA-K
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $43

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    10 mg

    $81

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    Product Description

    EUK 8 and EUK 134 (Item No. 10006329) are synthetic catalytic scavengers of reactive oxygen species with superoxide dismutase (SOD) and catalase mimetic activity.1 EUK 124 is a structural analog of EUK 8 and EUK 134 with significantly reduced activity. EUK 124 and EUK 8 inhibit superoxide-mediated reduction of an electron acceptor (i.e., SOD mimetic activity), with IC50 values of 5 µM and 0.7 µM, respectively.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Baker, K., Marcus, C.B., Huffman, K., et al. Synthetic combined superoxide dismutase/catalase mimetics are protective as a delayed treatment in a rat stroke model: A key role for reactive oxygen species in ischemic brain injury. J. Pharmacol. Exp. Ther. 284(1), 215-221 (1998).

    2. Doctrow, S.R., Huffman, K., Marcus, C.B., et al. Salen-manganese complexes as catalytic scavengers of hydrogen peroxide and cytoprotective agents: Structure-activity relationship studies. J. Med. Chem. 45(20), 4549-4558 (2002).