A stilbene with diverse biological activities
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Pterostilbene

Item No. 13000

Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[(1E)-2-(3,5-dimethoxyphenyl)ethenyl]-phenol
CAS Number
537-42-8
Synonyms
  • 3',5'-Dimethoxy Resveratrol
  • 3',5'-Dimethoxy-4-Stilbenol
  • trans-3,5-Dimethoxy-4'-Hydroxystilbene
Molecular Formula
C16H16O3
Formula Weight
256.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 50 mg/mlEthanol:PBS(pH 7.2) (1:5): 0.15 mg/ml
λmax
219, 309, 320 nm
SMILES
COc1cc(/C=C\c2ccc(O)cc2)cc(OC)c1
InChi Code
InChI=1S/C16H16O3/c1-18-15-9-13(10-16(11-15)19-2)4-3-12-5-7-14(17)8-6-12/h3-11,17H,1-2H3/b4-3+
InChi Key
VLEUZFDZJKSGMX-ONEGZZNKSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

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    250 mg

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    Cayman Chemical
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    Product Description

    Pterostilbene is a polyketide synthase-derived stilbene originally isolated from P. santalinus that has diverse biological activities.1,2,3,4,5 It reduces photooxidative leakage induced by the herbicide acifluorfen in C. sativus cotyledon disks when used at a concentration of 30 µg/ml.2 Pterostilbene (25 and 50 µM) inhibits invasion and migration of HepG2 hepatoma cells induced by 12-O-tetradecanoylphorbol 13-acetate (TPA; Item No. 10008014).3 It inhibits the production of nitric oxide (NO) and prostaglandin E2 (PGE2; Item No. 14010) in LPS-stimulated RAW 264.7 macrophages when used at concentrations of 10 and 20 µM.4 Pterostilbene (100 and 300 µM) activates peroxisome proliferator-activated receptor α (PPARα) in H4IIEC3 rat hepatoma cells.5 It decreases plasma glucose and LDL levels and increases plasma levels of HDL in a hamster model of hypercholesterolemia induced by a high-fat diet when administered in the diet at 25 ppm.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Austin, M.B., and Noel, J.P. The chalcone synthase superfamily of type III polyketide synthases. Nat. Prod. Rep. 20(1), 79-110 (2003).

    2. Rimando, A.M., Cuendet, M., Desmarchelier, C., et al. Cancer chemopreventive and antioxidant activities of pterostilbene, a naturally occurring analogue of resveratrol. J. Agric. Food Chem. 50(12), 3453-3457 (2002).

    3. Pan, M.-H., Chiou, Y.-S., Chen, W.-J., et al. Pterostilbene inhibited tumor invasion via suppressing multiple signal transduction pathways in human hepatocellular carcinoma cells. Carcinogenesis 30(7), 1234-1242 (2009).

    4. Pan, M.-H., Chang, Y.-H., Tsai, M.-L., et al. Pterostilbene suppressed lipopolysaccharide-induced up-expression of iNOS and COX-2 in murine macrophages. J. Agric. Food Chem. 56(16), 7502-7509 (2008).

    5. Rimando, A.M., Nagmani, R., Feller, D.R., et al. Pterostilbene, a new agonist for the peroxisome proliferator-activated receptor α-isoform, lowers plasma lipoproteins and cholesterol in hypercholesterolemic hamsters. J. Agric. Food Chem. 53(9), 3403-3407 (2005).