Prostaglandin E1 (CAS 745-65-3) | Cayman Chemical
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Prostaglandin E1

Item № 13010
CAS № 745-65-3
Purity ≥98%
product image
                (CAS 745-65-3)
     1 mg $17.00 0.00
     5 mg $72.00 0.00
     10 mg $102.00 0.00
     50 mg $468.00 0.00

Pricing updated 2018-12-14. Prices are subject to change without notice.

  • Alprostadil
  • PGE1

PGE1 is the theoretical cyclooxygenase metabolite of dihomo-γ-linolenic acid (DGLA), but it is virtually undetectable in the plasma of normal humans or other animals.1 Its pharmacology includes vasodilation, hypotension, and anti-platelet activities. The IC50 of PGE1 for the inhibition of ADP-induced human platelet aggregation is 40 nM.2,3 The vasorelaxant and anti-hypertensive effects of PGE1 are used to treat male erectile dysfunction and to provide emergency vasodilation of the patent ductus arteriosus in infants whose cardiac anomalies require pulmonary shunting for survival.4,5 In human males, the intracavernosal effective dose range for PGE1 is 2 to 80 µg, and the transurethral range is 125 to 1,000 µg.4

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Technical Information
Formal Name
9-oxo-11α,15S-dihydroxy-prost-13E-en-1-oic acid
CAS Number
  • Alprostadil
  • PGE1
Molecular Formula
Formula Weight
A crystalline solid
InChI Code
InChI Key

Warning - this product is not for human or veterinary use.

Shipping & Storage
Wet ice in continental US; may vary elsewhere
≥ 2 years
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References & Product Citations
Product Description References

1. Cawello, W., Schweer, H., Dietrich, B., et al. Pharmacokinetics of prostaglandin E1 and its main metabolites after intracavernous injection and short-term infusion of prostaglandin E1 in patients with erectile dysfunction Journal of Urology 158, 1403-1407 (1997).

2. Kobzar, G., Mardla, V., Järving, I., et al. Antiaggregating potency of E-type prostaglandins in human and rabbit platelets Proceedings of the Estonian Academy of Sciences.Chemistry 40, 179-180 (1991).

3. Okada, F., Nukada, T., Yamauchi, Y., et al. The hypotensive effect of prostaglandin E1 on hypertensive cases of various types Prostaglandins 7, 99-106 (1974).

4. Padma-Nathan, H., Hellstrom, W.J.G., Kaiser, F.E., et al. Treatment of men with erectile dysfunction with transurethral alprostadil New England Journal of Medicine 336, 1-7 (1997).

5. Olley, P.M., and Coceani, F. Prostaglandins and the ductus arteriosus Annual Reviews of Medicine 32, 375-3785 (1981).

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