An inactive metabolite of PGE1
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13,14-dihydro-15-keto Prostaglandin E1

Item No. 13650

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
11α-hydroxy-9,15-dioxo-prostan-1-oic acid
CAS Number
5094-14-4
Synonyms
  • 11α-Hydroxy-9,15-diketoprostanoic Acid
  • 15-keto-PGE0
  • 13,14-dihydro-15-keto PGE1
  • 15-keto-dihydro-PGE1
  • 15-keto Prostaglandin E0
Molecular Formula
C20H34O5
Formula Weight
354.5
Purity
≥98%
Formulation (Request formulation change)
A 10 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: >100 mg/ml (from PGE1)DMSO: >50 mg/ml (from PGE1)Ethanol: >50 mg/ml (from PGE1)PBS pH 7.2: >1.6 mg/ml (from PGE1)
SMILES
O[C@H]1[C@H](CCC(CCCCC)=O)[C@@H](CCCCCCC(OC)=O)C(C1)=O
InChi Code
InChI=1S/C21H36O5/c1-3-4-7-10-16(22)13-14-18-17(19(23)15-20(18)24)11-8-5-6-9-12-21(25)26-2/h17-18,20,24H,3-15H2,1-2H3/t17-,18-,20-/m1/s1
InChi Key
GLJUFUWUOYSGMU-QWFCFKBJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    10 mg

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    Product Description

    13,14-dihydro-15-keto Prostaglandin E1 (PGE1) is an inactive metabolite of PGE1 (Item No. 13010).1 It only weakly inhibits ADP-induced platelet aggregation in isolated human platelet-rich plasma (IC50 = 14.8 µg/ml) compared with PGE1.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Katzenschlager, R., Weiss, K., Rogatti, W., et al. Synergism between PGE1-metabolites(13,14-dihydro-prostaglandin E1, 15-keto prostaglandin E1, 15-keto-13,14-dihydro-prostaglandin E1) and nitric oxide (NO) on platelet aggregation. Prostaglandins Leukot. Essent. Fatty Acids 45(3), 207-210 (1992).