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2-Hydroxyestradiol

Item № 13019
CAS № 362-05-0
Purity ≥95%
product image
                (CAS 362-05-0)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     1 mg $35.00 0.00
     5 mg $158.00 0.00
     10 mg $298.00 0.00
     25 mg $656.00 0.00

Pricing updated 2019-07-23. Prices are subject to change without notice.

Description
Synonyms
  • 2-HE2
  • NSC 61711

2-hydroxy Estradiol (2-HE2) is a cytochrome P450 metabolite of estradiol with low affinity for estrogen receptors. 2-HE is rapidly metabolized by catechol-O-methyltransferase (COMT) to form 2-methoxy estradiol (2-ME2) with a half-life of approximately ten minutes in rat.1 2-ME2 has achieved considerable attention as an anti-cancer agent acting as an angiogenesis inhibitor via the HIF-1a pathway.2,3,4 Due to the rapid metabolism of 2-HE2, the effects attributed to 2-HE2, may actually be those of 2-ME2.1

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Technical Information
Formal Name
estra-1,3,5(10)-triene-2,3,17β-triol
CAS Number
362-05-0
Synonyms
  • 2-HE2
  • NSC 61711
Molecular Formula
C18H24O3
Formula Weight
288.4
Purity
≥95%
Formulation
A crystalline solid
SMILES
OC1=C(O)C=C(CC[C@]2([H])[C@]3([H])CC[C@@]4(C)[C@@]2([H])CC[C@@H]4O)C3=C1
InChI Code
InChI=1S/C18H24O3/c1-18-7-6-11-12(14(18)4-5-17(18)21)3-2-10-8-15(19)16(20)9-13(10)11/h8-9,11-12,14,17,19-21H,2-7H2,1H3/t11-,12+,14-,17-,18-/m0/s1
InChI Key
DILDHNKDVHLEQB-XSSYPUMDSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
Downloads & Resources
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Additional Information

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References & Product Citations
Product Description References

1. Zacharia, L.C., Piché, C.A., Fielding, R.M., et al. 2-hydroxyestradiol is a prodrug of 2-methoxyestradiol Journal of Pharmacology and Experimental Therapeutics 309(3), 1093-1097 (2004).

2. Mooberry, S.L. New insights into 2-methoxyestradiol, a promising antiangiogenic and antitumor agent Current Opinion in Oncology 15, 425-430 (2003).

3. Mooberry, S.L. Mechanism of action of 2-methoxyestradiol: New developments Drug Resistance Updates 6, 355-361 (2003).

4. Becker, C.M., Rohwer, N., Funakoshi, T., et al. 2-methoxyestradiol inhibits hypoxia-inducible factor-1α and suppressess growth of lesions in a mouse model of endometriosis American Journal of Pathology 172(2), 534-544 (2008).

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