An ellagitannin with antioxidant, anti-inflammatory, and anticancer effects
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Punicalagin

Item No. 13069

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
cyclic 4,6-[(2S,2'S)-2,2'-(5,10-dihydro-2,3,7,8-tetrahydroxy-5,10-dioxo[1]benzopyrano[5,4,3-cde][1]benzopyran-1,6-diyl)bis[3,4,5-trihydroxybenzoate]] cyclic 2,3-[(1S)-4,4',5,5',6,6'-hexahydroxy[1,1'-biphenyl]-2,2'-dicarboxylate]-D-glucose
CAS Number
65995-63-3
Molecular Formula
C48H28O30
Formula Weight
1084.7
Purity
≥95% mixture of anomers
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 10 mg/mlEthanol: 15 mg/mlPBS (pH 7.2): 5 mg/ml
λmax
217, 260, 379 nm
SMILES
O=C(O1)C2=C(C3=C(O)C(O)=C2C4=C(O)C(O)=C(O)C=C4C5=O)C6=C1C(O)=C(O)C(C7=C(O)C(O)=C(O)C=C7C(OCC(O)C(C8C(C=O)OC(C9=CC(O)=C(O)C(O)=C9C%10=C(C(O8)=O)C=C(O)C(O)=C%10O)=O)O5)=O)=C6C(O3)=O
InChi Code
InChI=1S/C48H28O30/c49-5-16-40(76-46(70)9-3-13(52)28(56)32(60)18(9)17-8(44(68)74-16)2-12(51)27(55)31(17)59)39-15(54)6-73-43(67)7-1-11(50)29(57)33(61)19(7)21-25-23-24-26(48(72)78-41(23)37(65)35(21)63)22(36(64)38(66)42(24)77-47(25)71)20-10(45(69)75-39)
InChi Key
SKNLUADAGHCXKF-UHFFFAOYSA-N
Origin
Plant/Pomegranate rind
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $28

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    5 mg

    $104

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    10 mg

    $193

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    25 mg

    $413

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Punicalagin is a major ellagitannin found in pomegranates that is reported to produce antioxidant, anti-inflammatory, and anticancer effects.1 It has been shown to prevent high-fat diet-induced obesity-associated accumulation of cardiac triglyceride and cholesterol, as well as myocardial damage, via AMPK-mediated modulation of mitochondria and phase II enzymes.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Seeram, N.P., Adams, L.S., Henning, S.M., et al. In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice. J. Nutr. Biochem. 16(6), 360-367 (2005).

    2. Cao, K., Pu, W., Dong, Z., et al. Punicalagin, an active component in pomegranate, ameliorates cardiac mitochondrial impairment in obese rats via AMPK activation. Sci. Rep. 5, 14014 (2015).