A fungal metabolite that blocks glucagon signaling
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Isomer(s)
341433,8'-Biapigenin 35237Sennidin A
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Skyrin

Item No. 13102

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,2',4,4',5,5'-hexahydroxy-7,7'-dimethyl-[1S,1'-bianthracene]-9,9',10,10'-tetrone
CAS Number
602-06-2
Synonyms
  • Endothianin
  • Rhodophyscin
Molecular Formula
C30H18O10
Formula Weight
538.5
Purity
≥97%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleEthanol: soluble
SMILES
CC1=CC(O)=C2C(C(C(C(C3=C(O)C=C(O)C(C(C4=C5C=C(C)C=C4O)=O)=C3C5=O)=C(O)C=C6O)=C6C2=O)=O)=C1
InChi Code
InChI=1S/C30H18O10/c1-9-3-11-19(13(31)5-9)29(39)23-17(35)7-15(33)21(25(23)27(11)37)22-16(34)8-18(36)24-26(22)28(38)12-4-10(2)6-14(32)20(12)30(24)40/h3-8,31-36H,1-2H3
InChi Key
MQSXZQXHIJMNAF-UHFFFAOYSA-N
Origin
Fungus/Penicillium sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $280

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    Product Description

    Skyrin is a fungal metabolite characterized by a bisanthraquinone structure. It interferes with glucagon signaling through adenylate cyclase without binding to the glucagon receptor.1 At 10 μM, skyrin reduces both glucagon-stimulated cAMP production and glycogenolysis.1 It does not interfere with epinephrine or glucagon-like peptide 1 effects on these parameters.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Parker, J.C., McPherson, R.K., Andrews, K.M., et al. Effects of skyrin, a receptor-selective glucagon antagonist, in rat and human hepatocytes. Diabetes 49, 2079-2086 (2012).