An active metabolite of sennoside A
Related Products
Isomer(s)
13102Skyrin
Parent Compound(s)
24969Sennoside A
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Sennidin A

Item No. 35237

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(9R,9′R)-rel-(+)-9,9′,10,10′-tetrahydro-4,4′,5,5′-tetrahydroxy-10,10′-dioxo-[9,9′-bianthracene]-2,2′-dicarboxylic acid
CAS Number
641-12-3
Molecular Formula
C30H18O10
Formula Weight
538.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: SolubleMethanol: Soluble
SMILES
O=C1C2=C(O)C=C(C(O)=O)C=C2[C@@]([C@@]3([H])C4=CC(C(O)=O)=CC(O)=C4C(C5=C(O)C=CC=C53)=O)([H])C6=CC=CC(O)=C61
InChi Code
InChI=1S/C30H18O10/c31-17-5-1-3-13-21(15-7-11(29(37)38)9-19(33)25(15)27(35)23(13)17)22-14-4-2-6-18(32)24(14)28(36)26-16(22)8-12(30(39)40)10-20(26)34/h1-10,21-22,31-34H,(H,37,38)(H,39,40)/t21-,22-/m1/s1
InChi Key
JPMRHWLJLNKRTJ-FGZHOGPDSA-N
Origin
Plant/Sennae folium
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    1 mg

    $73

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    5 mg

    $235

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    10 mg

    $324

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    Product Description

    Sennidin A is an active metabolite of the dianthrone glycoside laxative sennoside A (Item No. 24969) that has also been found in Senna.1,2 It is formed from sennoside A by gut microbiota.1 Sennidin A increases fecal excretion in mice in a dose-dependent manner.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hattori, M., Kim, G., Motoike, S., et al. Metabolism of sennosides by intestinal flora. Chem. Pharm. Bull. (Tokyo) 30(4), 1338-1346 (1982).

    2. Metzger, W., and Reif, K. Determination of 1,8-dihydroxyanthranoids in senna. J. Chromatogr. A 740, 133-138 (1996).

    3. Fairbairn, J.W., and Moss, M.J. The relative purgative activities of 1,8-dihydroxyanthracene derivatives. J. Pharm. Pharmacol. 22(8), 584-593 (1970).