A DNA-crosslinking agent
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Labeled Version(s)
34408Oxaliplatin-d10
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Oxaliplatin

Item No. 13106

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(SP-4-2)-[1R,2R-cyclohexanediamine-κN1,κN2][ethanedioato(2-)-κO1,κO2]-platinum
CAS Number
61825-94-3
Synonyms
  • Lipoxal
  • NSC 266046
  • RP 54780
Molecular Formula
C8H14N2O4Pt
Formula Weight
397.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 0.01 mg/ml
SMILES
O=C1[O-][Pt+2]2([O-]C1=O)[NH2][C@@]3([H])[C@](CCCC3)([H])[NH2]2
InChi Code
InChI=1S/C6H14N2.C2H2O4.Pt/c7-5-3-1-2-4-6(5)8;3-1(4)2(5)6;/h5-6H,1-4,7-8H2;(H,3,4)(H,5,6);/q;;+2/p-2/t5-,6-;;/m1../s1
InChi Key
ZROHGHOFXNOHSO-BNTLRKBRSA-L
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

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    Cayman Chemical
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    Product Description

    Oxaliplatin is a platinum-containing DNA-crosslinking agent.1 It induces the formation of DNA inter- and intrastrand crosslinks and DNA-protein crosslinks, inhibits DNA and RNA synthesis, and induces apoptosis in cancer cells. Oxaliplatin is cytotoxic to cisplatin-sensitive A2780(1A9) and KB-3-1 cells and cisplatin-resistant A2780-E(80) and KB-CP20 cells (IC50s = 0.12, 0.39, 4.7, and 2.7 µM, respectively).2 It reduces tumor growth in an HCCLM3 mouse xenograft model when administered at doses of 5 or 10 mg/kg once per week.3 Formulations containing oxaliplatin have been used in the treatment of advanced colorectal cancer and as an adjuvant in stage III colon cancer.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Alcindor, T., and Beauger, N. Oxaliplatin: A review in the era of molecularly targeted therapy. Curr. Oncol. 18(1), 18-25 (2011).

    2. Rixe, O., Ortuzar, W., Alvarez, M., et al. Oxaliplatin, tetraplatin, cisplatin, and carboplatin: Spectrum of activity in drug-resistant cell lines and in the cell lines of the National Cancer Institute’s Anticancer Drug Screen panel. Biochem. Pharmacol. 52(12), 1855-1865 (1996).

    3. Wang, Z., Zhou, J., Fan, J., et al. Oxaliplatin induces apoptosis in hepatocellular carcinoma cells and inhibits tumor growth. Expert Opin. Investig. Drugs 18(11), 1595-1604 (2009).