An internal standard for the quantification of oxaliplatin
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Unlabeled Version(s)
13106Oxaliplatin
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Oxaliplatin-d10

Item No. 34408

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(SP-4-2)-[(1R,2R)-1,2-cyclohexane-1,2,3,3,4,4,5,5,6,6-d10-diamine-κN1,κN2][ethanedioato(2-)-κO1,κO2]-platinum
CAS Number
1132819-16-9
Synonyms
  • Lipoxal-d10
Molecular Formula
C8H4D10N2O4Pt
Formula Weight
407.4
Purity
≥99% deuterated forms (d1-d10)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: slightly solubleWater: slightly, sonicated
SMILES
O=C1[O-][Pt+2]2([O-]C1=O)[NH2][C@@](C([2H])([2H])C([2H])([2H])C([2H])([2H])C3([2H])[2H])([2H])[C@]3([2H])[NH2]2
InChi Code
InChI=1S/C6H14N2.C2H2O4.Pt/c7-5-3-1-2-4-6(5)8;3-1(4)2(5)6;/h5-6H,1-4,7-8H2;(H,3,4)(H,5,6);/q;;+2/p-2/t5-,6-;;/m1../s1/i1D2,2D2,3D2,4D2,5D,6D;;
InChi Key
ZROHGHOFXNOHSO-YYKMXZQESA-L
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $1,056

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    Product Description

    Oxaliplatin-d10 is intended for use as an internal standard for the quantification of oxaliplatin (Item No. 13106) by GC- or LC-MS. Oxaliplatin is a platinum-containing DNA-crosslinking agent.1 It induces the formation of DNA inter- and intrastrand crosslinks and DNA-protein adducts, inhibits DNA and RNA synthesis, and induces apoptosis in cancer cells. Oxaliplatin is cytotoxic to cisplatin-sensitive A2780(1A9) and KB-3-1 cells and cisplatin-resistant A2780-E(80) and KB-CP20 cells (IC50s = 0.12, 0.39, 4.7, and 2.7 µM, respectively).2 It reduces tumor growth in an HCCLM3 mouse xenograft model when administered at doses of 5 or 10 mg/kg once per week.3 Formulations containing oxaliplatin have been used in the treatment of advanced colorectal cancer and as adjuvants in stage III colon cancer.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Alcindor, T., and Beauger, N. Oxaliplatin: A review in the era of molecularly targeted therapy. Curr. Oncol. 18(1), 18-25 (2011).

    2. Rixe, O., Ortuzar, W., Alvarez, M., et al. Oxaliplatin, tetraplatin, cisplatin, and carboplatin: Spectrum of activity in drug-resistant cell lines and in the cell lines of the National Cancer Institute’s Anticancer Drug Screen panel. Biochem. Pharmacol. 52(12), 1855-1865 (1996).

    3. Wang, Z., Zhou, J., Fan, J., et al. Oxaliplatin induces apoptosis in hepatocellular carcinoma cells and inhibits tumor growth. Expert Opin. Investig. Drugs 18(11), 1595-1604 (2009).