An Hsp90 inhibitor
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Isomer(s)
37533Pyraclostrobin
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VER-49009

Item No. 13131

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(4-methoxyphenyl)-1H-pyrazole-5-carboxamide
CAS Number
558640-51-0
Molecular Formula
C19H18ClN3O4
Formula Weight
387.8
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
SMILES
ClC1=C(O)C=C(O)C(C2=NNC(C(NCC)=O)=C2C3=CC=C(OC)C=C3)=C1
InChi Code
InChI=1S/C19H18ClN3O4/c1-3-21-19(26)18-16(10-4-6-11(27-2)7-5-10)17(22-23-18)12-8-13(20)15(25)9-14(12)24/h4-9,24-25H,3H2,1-2H3,(H,21,26)(H,22,23)
InChi Key
HUNAOTXNHVALTN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $36

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    5 mg

    $97

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    10 mg

    $159

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    Cayman Chemical
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    Product Description

    The heat shock proteins (Hsps) act as molecular chaperones. Hsp90 is an abundant protein with roles in protein folding, cell signaling, and cancer. VER-49009 is a pyrazole compound that inhibits Hsp90 with an IC50 value of 47 nM.1 It produces a cellular antiproliferative GI50 value of 685 nM when tested against a human cancer cell line panel.1 Consistent with inhibition of Hsp90, VER-49009 induces the expression of Hsp27 and Hsp72 while reducing the client proteins c-Raf, B-Raf, survivin, and PRMT5, causing cell cycle arrest and apoptosis.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sharp, S.Y., Prodromou, C., Boxall, K., et al. Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues. Mol. Cancer Ther. 6(4), 1198-1211 (2007).