Pyraclostrobin

Pyraclostrobin is a carbamate fungicide.¹ It is active against the plant pathogenic fungi B. cinerea, P. capsici, F. sulphureum, G. pestis, and S. sclerotiorum (IC₅₀s = 0.18, 0.005, 0.36, 0.03, and 0.15 µg/ml, respectively). Pyraclostrobin is toxic to zebrafish (LC₅₀ = 42.17 µg/L).² It induces nuclear and mitochondrial deformities in the heart and brain, as well as decreases heart rate, blood volume ejected, and cardiac output, in zebrafish larvae when used at a concentration of 37.5 µg/L. Pyraclostrobin (400 mg/kg) decreases locomotor activity and body weight, as well as induces hypothermia and diarrhea, in mice.³ Formulations containing pyraclostrobin have been used as fungicides in agriculture.

WARNING This product is not for human or veterinary use.

1. Wang, L., Zhao, S., Kong, X., et al. Design, synthesis and fungicidal evaluation of novel pyraclostrobin analogues. Bioorg. Med. Chem. 26(4), 875-883 (2018).

2. Li, H., Zhao, F., Cao, F., et al. Mitochondrial dysfunction-based cardiotoxicity and neurotoxicity induced by pyraclostrobin in zebrafish larvae. Environ. Pollut. 251, 203-211 (2019).

3. Tuttle, A.H., Salazar, G., Cooper, E.M., et al. Choice of vehicle affects pyraclostrobin toxicity in mice. Chemosphere 218, 501-506 (2019).