A selective FFAR1 (GPR40) agonist
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CAY10587

Item No. 13143

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[2-(2-methylphenyl)ethynyl]-benzenepropanoic acid
CAS Number
1082058-99-8
Molecular Formula
C18H16O2
Formula Weight
264.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 15 mg/ml
λmax
286, 295, 305 nm
SMILES
CC1=C(C#CC2=CC=C(CCC(O)=O)C=C2)C=CC=C1
InChi Code
InChI=1S/C18H16O2/c1-14-4-2-3-5-17(14)12-10-15-6-8-16(9-7-15)11-13-18(19)20/h2-9H,11,13H2,1H3,(H,19,20)
InChi Key
FODHWOBAQBTTFS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $37

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    5 mg

    $158

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    10 mg

    $280

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    25 mg

    $609

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    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

    Discover high-quality research tools to investigate GLP-1 mechanisms and next-generation metabolic targets.

    OBESITY RESEARCH SOLUTIONS
    Product Description

    CAY10587 is a selective FFAR1 (GPR40) agonist (EC50 = 32 nM) that does not exhibit activity on the related FFARs: FFAR2 (GPR43) or FFAR3 (GPR41).1 At 100 nM, CAY10587 increases glucose-stimulated insulin secretion in the rat insulin-secreting cell line INS-1E.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Christiansen, E., Urban, C., Merten, N., et al. Discovery of potent and selective agonists for the free fatty acid receptor 1 (FFA1/GPR40), a potential target for the treatment of type II diabetes. J. Med. Chem. 51(22), 7061-7064 (2008).