M 344

M 344 is an inhibitor of histone deacetylases (HDACs), inhibiting maize HDAC (IC₅₀ = 100 nM)¹ as well as human HDAC1 (IC₅₀ = 46 nM).² It shows a three-fold selectivity for inhibition of HDAC6 over HDAC1 (IC₅₀s = 88 and 249 nM, respectively).³ M 344 enhances the sensitivity of human squamous carcinoma cells to radiation⁴ and promotes cell cycle arrest and apoptosis in human endometrial cancer and ovarian cancer cells (ED₅₀ = 2.3 μM).⁵

WARNING This product is not for human or veterinary use.

1. Jung, M., Brosch, G., Kölle, D., et al. Amide analogues of trichostatin A as inhibitors of histone deacetylase and inducers of terminal cell differentiation. J. Med. Chem. 42(22), 4669-4679 (1999).

2. Remiszewski, S.W., Sambucetti, L.C., Atadja, P., et al. Inhibitors of human histone deacetylase: Synthesis and enzyme and cellular activity of straight chain hydroxamates. J. Med. Chem. 45(4), 753-757 (2002).

3. Heltweg, B., Dequiedt, F., Marshall, B.L., et al. Subtype selective substrates for histone deacetylases. J. Med. Chem. 47(21), 5235-5243 (2004).

4. Zhang, Y., Jung, M., Dritschilo, A., et al. Enhancement of radiation sensitivity of human squamous carcinoma cells by histone deacetylase inhibitors. Radiat. Res. 161(6), 667-674 (2004).

5. Takai, N., Ueda, T., Nishida, M., et al. M344 is a novel synthesized histone deacetylase inhibitor that induces growth inhibition, cell cycle arrest, and apoptosis in human endometrial cancer and ovarian cancer cells. Gynecol. Oncol. 101(1), 108-113 (2006).