HDAC inhibitor
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M 344

Item No. 13174

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-benzamide
CAS Number
251456-60-7
Synonyms
  • D237
  • Histone Deacetylase Inhibitor III
  • MS 344
Molecular Formula
C16H25N3O3
Formula Weight
307.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 25 mg/mlEthanol: 3 mg/ml
λmax
301 nm
SMILES
ONC(=O)CCCCCCNC(=O)c1ccc(cc1)N(C)C
InChi Code
InChI=1S/C16H25N3O3/c1-19(2)14-10-8-13(9-11-14)16(21)17-12-6-4-3-5-7-15(20)18-22/h8-11,22H,3-7,12H2,1-2H3,(H,17,21)(H,18,20)
InChi Key
MXWDSZWTBOCWBK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

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    5 mg

    $72

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    10 mg

    $134

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    25 mg

    $315

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    50 mg

    $556

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    Cayman Chemical
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    Product Description

    M 344 is an inhibitor of histone deacetylases (HDACs), inhibiting maize HDAC (IC50 = 100 nM)1 as well as human HDAC1 (IC50 = 46 nM).2 It shows a three-fold selectivity for inhibition of HDAC6 over HDAC1 (IC50s = 88 and 249 nM, respectively).3 M 344 enhances the sensitivity of human squamous carcinoma cells to radiation4 and promotes cell cycle arrest and apoptosis in human endometrial cancer and ovarian cancer cells (ED50 = 2.3 μM).5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jung, M., Brosch, G., Kölle, D., et al. Amide analogues of trichostatin A as inhibitors of histone deacetylase and inducers of terminal cell differentiation. J. Med. Chem. 42(22), 4669-4679 (1999).

    2. Remiszewski, S.W., Sambucetti, L.C., Atadja, P., et al. Inhibitors of human histone deacetylase: Synthesis and enzyme and cellular activity of straight chain hydroxamates. J. Med. Chem. 45(4), 753-757 (2002).

    3. Heltweg, B., Dequiedt, F., Marshall, B.L., et al. Subtype selective substrates for histone deacetylases. J. Med. Chem. 47(21), 5235-5243 (2004).

    4. Zhang, Y., Jung, M., Dritschilo, A., et al. Enhancement of radiation sensitivity of human squamous carcinoma cells by histone deacetylase inhibitors. Radiat. Res. 161(6), 667-674 (2004).

    5. Takai, N., Ueda, T., Nishida, M., et al. M344 is a novel synthesized histone deacetylase inhibitor that induces growth inhibition, cell cycle arrest, and apoptosis in human endometrial cancer and ovarian cancer cells. Gynecol. Oncol. 101(1), 108-113 (2006).