A sirtuin inhibitor
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Salermide

Item No. 13178

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[3-[[(2-hydroxy-1-naphthalenyl)methylene]amino]phenyl]-a-methyl-benzeneacetamide
CAS Number
1105698-15-4
Molecular Formula
C26H22N2O2
Formula Weight
394.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:2): 0.25 mg/ml
λmax
207, 233, 318, 365, 440, 459 nm
SMILES
OC1=CC=C2C=CC=CC2=C1/C=N/C3=CC(NC(C(C)C4=CC=CC=C4)=O)=CC=C3
InChi Code
InChI=1S/C26H22N2O2/c1-18(19-8-3-2-4-9-19)26(30)28-22-12-7-11-21(16-22)27-17-24-23-13-6-5-10-20(23)14-15-25(24)29/h2-18,29H,1H3,(H,28,30)/b27-17+
InChi Key
HQSSEGBEYORUBY-WPWMEQJKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    Cayman Chemical
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    Product Description

    The sirtuins (SIRTs) are a family of NAD+-dependent histone deacetylases involved in gene regulation that is relevant to, e.g., longevity, cancer, gene regulation, energy homeostasis, and apoptosis.1,2 Salermide is an inhibitor of SIRT1 and SIRT2, causing tumor-specific apoptotic cell death.3 In MOLT4 leukemia cells, salermide causes 90% apoptosis within 72 hours (IC50 ~20 μM) by reactivating proapototic genes that are repressed by SIRT1.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yamamoto, H., Schoonjans, K., and Auwerx, J. Sirtuin functions in health and disease. Mol. Endocrinol. 21(8), 1745-1755 (2007).

    2. Milne, J.C., and Denu, J.M. The sirtuin family: Therapeutic targets to treat diseases of aging. Curr. Opin. Chem. Biol. 12(1), 11-17 (2008).

    3. Lara, E., Mai, A., Calvanese, V., et al. Salermide, a sirtuin inhibitor with a strong cancer-specific proapoptotic effect. Oncogene 28(6), 781-791 (2008).