An inhibitor of VEGFR2, FGFR1, and PDGFRβ
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SU 5402

Item No. 13182

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-4-methyl-1H-pyrrole-3-propanoic acid
CAS Number
215543-92-3
Molecular Formula
C17H16N2O3
Formula Weight
296.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 30 mg/ml
λmax
210, 275, 430 nm
SMILES
O=C(/C1=C\C2=C(CCC(O)=O)C(C)=CN2)NC3=C1C=CC=C3
InChi Code
InChI=1S/C17H16N2O3/c1-10-9-18-15(11(10)6-7-16(20)21)8-13-12-4-2-3-5-14(12)19-17(13)22/h2-5,8-9,18H,6-7H2,1H3,(H,19,22)(H,20,21)/b13-8-
InChi Key
JNDVEAXZWJIOKB-JYRVWZFOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $31

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    5 mg

    $77

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    10 mg

    $139

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    25 mg

    $270

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    Product Description

    SU 5402 is an inhibitor of the tyrosine kinase domains of VEGFR2, FGFR1, and PDGFRβ (IC50s = 0.02, 0.03, and 0.51 µM, respectively).1 It is much less effective against other receptor tyrosine kinases.1 SU 5402 is commonly used to evaluate the role of FGFR1 in cellular functions.2,3,4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sun, L., Tran, N., Liang, C., et al. Design, synthesis, and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF, and PDGF receptor tyrosine kinases. J. Med. Chem. 42(25), 5120-5130 (1999).

    2. Heryanto, B., Lipson, K.E., and Rogers, P.A.W. Effect of angiogenesis inhibitors on oestrogen-mediated endometrial endothelial cell proliferation in the ovariectomized mouse. Reproduction 125, 337-346 (2003).

    3. Ying, Q.L., Wray, J., Nichols, J., et al. The ground state of embryonic stem cell self-renewal. Nature 453(7194), 519-524 (2008).

    4. Hasse, C., Holz, O., Lange, E., et al. FGFR-ERK signaling is an essential component of tissue separation. Dev. Biol. 395(1), 154-166 (2014).

    5. Kachel, P., Trojanowicz, B., Sekulla, C., et al. Phosphorylation of pyruvate kinase M2 and lactate dehydrogenase A by fibroblast growth factor receptor 1 in benign and malignant thyroid tissue. BMC Cancer 15:140, (2015).