Pricing updated 2019-04-24. Prices are subject to change without notice.
Sphingosine-1-phosphate (S1P; Item No. 62570) is a bioactive lipid that exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis.1,2,3 It exerts its activity by binding to five distinct G protein-coupled receptors, S1P1/EDG-1, S1P2/EDG-5, S1P3/EDG-3, S1P4/EDG-6, and S1P5/EDG-8.1,2 VPC 23019 is an aryl amide-containing S1P analog that acts as a competitive antagonist at both S1P1 and S1P3 receptors (pKis = 7.86 and 5.93, respectively).4 It can inhibit S1P-induced migration of thyroid cancer cells, ovarian cancer cells, and neural stem cells.5
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Takuwa, Y., Takuwa, N., and Sugimoto, N. The Edg family G protein-
2. Ishii, I., Fukushima, N., Ye, X., et al. Lysophospholipid receptors: Signaling and biology Annu. Rev. Biochem. 73, 321-354 (2004).
Kluk, M.J., and Hla, T. Signaling of sphingosine-
Davis, M.D., Clemens, J.J., Macdonald, T.L., et al. Sphingosine 1-
Takabe, K., Paugh, S.W., Milstien, S., et al. "Inside-