An enantiomer of L-DOPA
Related Products
Enantiomer(s)
13248L-DOPA
Isomer(s)
36382Forphenicinol
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

D-DOPA

Item No. 13249

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-hydroxy-D-tyrosine
CAS Number
5796-17-8
Molecular Formula
C9H11NO4
Formula Weight
197.2
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
0.1 M HCl: 10 mg/ml
SMILES
OC1=CC(C[C@@H](N)C(O)=O)=CC=C1O
InChi Code
InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)
InChi Key
WTDRDQBEARUVNC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    50 mg

    $63

    Add

    100 mg

    $118

    Add

    250 mg

    $242

    Add

    500 mg

    $392

    Add
    Product Description

    D-DOPA is an enantiomer of the dopamine precursor L-DOPA (Item No. 13248). It can be converted to L-DOPA via sequential oxidation and transamination, which are mediated by D-amino acid oxidase (DAAO) and DOPA transaminase, respectively, in rat kidney homogenates.1 It reduces the number of dopaminergic neurons in primary rat embryonic mesencephalic cultures in a concentration-dependent manner.2 Intraventricular administration of D-DOPA (200 µg/animal) increases striatal dopamine levels in rats.3 D-DOPA (20 mg/kg, i.p.) induces contralateral turns in a rat model of Parkinson's disease induced by 6-OHDA (Item No. 25330).4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wu, M., Zhou, X.-J., Konno, R., et al. D-dopa is unidirectionally converted to L-dopa by D-amino acid oxidase, followed by dopa transaminase. Clin. Exp. Pharmacol. Physiol. 33(11), 1042-1046 (2006).

    2. Ling, Z.-D., Pieri, S.C., and Carvey, P.M. Comparison of the neurotoxicity of dihydroxyphenylalanine stereoisomers in cultured dopamine neurons. Clin. Neuropharmacol. 19(4), 360-365 (1996).

    3. Karoum, F., Freed, W.J., Chuang, L.-W., et al. D-dopa and L-dopa similarly elevate brain dopamine and produce turning behavior in rats. Brain Res. 440(1), 190-194 (1988).

    4. Moses, J., Siddiqui, A., and Silverman, P.B. Sodium benzoate differentially blocks circling induced by D-and L-dopa in the hemi-parkinsonian rat. Neurosci. Lett. 218(3), 145-148 (1996).