A catecholaminergic neurotoxin
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6-OHDA (hydrobromide)

Item No. 25330

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-(2-aminoethyl)-1,2,4-benzenetriol, monohydrobromide
CAS Number
636-00-0
Synonyms
  • 6-hydroxy Dopamine
  • Oxidopamine
  • 2,4,5-Trihydroxyphenethylamine
Molecular Formula
C8H11NO3 • HBr
Formula Weight
250.1
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 15 mg/mlEthanol: 5 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
296 nm
SMILES
OC1=CC(O)=C(CCN)C=C1O.Br
InChi Code
InChI=1S/C8H11NO3.BrH/c9-2-1-5-3-7(11)8(12)4-6(5)10;/h3-4,10-12H,1-2,9H2;1H
InChi Key
MLACDGUOKDOLGC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

    $43

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    250 mg

    $161

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    1 g

    $515

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    Cayman Chemical
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    Product Description

    6-OHDA is a catecholaminergic neurotoxin that has been used to induce dopaminergic lesions and parkinsonian symptoms as a model of Parkinson's disease in rodents.1 It induces locomotor impairment in mice and loss of tyrosine hydroxylase-reactive neurons in mouse brain when administered into the substantia nigra, medial forebrain bundle (MFB), or striatum at doses of 9, 6, and 18 μg, respectively.2 Intracisternal administration of 6-OHDA (200 μg) decreases dopamine (Item No. 21992) and norepinephrine (Item No. 16673) levels in rat brain.3 It induces apoptosis in primary rat cortical cells and PC12 rat adrenal cells when used at a concentration of 50 μM.4,5 6-OHDA (75 μM) activates caspase-3, -8, and -9 in a time-dependent manner and increases the level of intracellular reactive oxygen species (ROS) in PC12 cells and induces apoptosis in rat substantia nigra when stereotaxically injected into the right MFB.5,6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Blum, D., Torch, S., Lambeng, N., et al. Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: Contribution to the apoptotic theory in Parkinson’s disease. Prog. Neurobiol. 65(2), 135-172 (2001).

    2. Heuer, A., Smith, G.A., Lelos, M.J., et al. Unilateral nigrostriatal 6-hydroxydopamine lesions in mice I: Motor impairments identify extent of dopamine depletion at three different lesion sites. Behav. Brain Res. 228(1), 30-43 (2012).

    3. Breese, G.R., and Traylor, T.D. Effect of 6-hydroxydopamine on brain norepinephrine and dopamine: Evidence for selective degeneration of catecholamine neurons. J. Pharmacol. Exp. Ther. 174(3), 413-420 (1970).

    4. Han, B.S., Noh, J.S., Gwag, B.J., et al. A distinct death mechanism is induced by 1-methyl-4-phenylpyridinium or by 6-hydroxydopamine in cultured rat cortical neurons: Degradation and dephosphorylation of tau. Neurosci. Lett. 341(2), 99-102 (2003).

    5. Fujita, H., Ogino, T., Kobuchi, H., et al. Cell-permeable cAMP analog suppresses 6-hydroxydopamine-induced apoptosis in PC12 cells through the activation of the Akt pathway. Brain Res. 1113(1), 10-23 (2006).

    6. He, Y., Lee, T., and Leong, S.K. 6-Hydroxydopamine induced apoptosis of dopaminergic cells in the rat substantia nigra. Brain Res. 858(1), 163-166 (2000).