An HDAC1 and HDAC3 inhibitor
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MS-275

Item No. 13284

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[[4-[[(2-aminophenyl)amino]carbonyl]phenyl]methyl]-carbamic acid, 3-pyridinylmethyl ester
CAS Number
209783-80-2
Synonyms
  • Entinostat
  • MS-27-275
  • SNDX-275
Molecular Formula
C21H20N4O3
Formula Weight
376.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mlEthanol: 2 mg/ml
λmax
204, 233, 299 nm
SMILES
O=C(NCC1=CC=C(C(NC2=C(N)C=CC=C2)=O)C=C1)OCC3=CC=CN=C3
InChi Code
InChI=1S/C21H20N4O3/c22-18-5-1-2-6-19(18)25-20(26)17-9-7-15(8-10-17)13-24-21(27)28-14-16-4-3-11-23-12-16/h1-12H,13-14,22H2,(H,24,27)(H,25,26)
InChi Key
INVTYAOGFAGBOE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    25 mg

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    Product Description

    MS-275 is an inhibitor of histone deacetylase 1 (HDAC1) and HDAC3 (IC50s = 0.3 and 8 µM, respectively).1 It is selective for HDAC1 and HDAC3 over HDAC8 (IC50 = >100 µM). MS-275 decreases the proliferation of A2780 ovarian, Calu-3 lung, HL-60 promyeloblast leukemia, and K562 chronic myeloid leukemia (CML) cells (IC50s = 0.0415, 0.195, 0.212, and 0.589 µM, respectively). It induces cell cycle arrest at the G1 phase in A2780 cells when used at a concentration of 1 µM. MS-275 (49 mg/kg per day) decreases tumor volume and increases intratumoral histone H4 acetylation in an HT-29 colon cancer mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hu, E., Dul, E., Sung, C.M., et al. Identification of novel isoform-selective inhibitors within class I histone deacetylases. J. Pharmacol. Exp. Ther. 307(2), 720-728 (2003).