Inhibitor of DNA-dependent protein kinase
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NU 7026

Item No. 13308

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(4-morpholinyl)-4H-naphtho[1,2-b]pyran-4-one
CAS Number
154447-35-5
Synonyms
  • DNA-PK Inhibitor II
  • LY293646
Molecular Formula
C17H15NO3
Formula Weight
281.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 0.15 mg/ml
λmax
219, 255, 315 nm
SMILES
O=C1C=C(N2CCOCC2)OC3=C4C=CC=CC4=CC=C31
InChi Code
InChI=1S/C17H15NO3/c19-15-11-16(18-7-9-20-10-8-18)21-17-13-4-2-1-3-12(13)5-6-14(15)17/h1-6,11H,7-10H2
InChi Key
KKTZALUTXUZPSN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $90

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    10 mg

    $168

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    25 mg

    $392

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    50 mg

    $696

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    Product Description

    DNA-dependent protein kinase (DNA-PK) binds to strand breaks produced during normal cellular processes or in response to genotoxic stresses, such as ionizing radiation, targeting substrates that facilitate DNA repair. NU 7026 is a cell-permeable, potent, specific, and ATP-competitive inhibitor of DNA-PK (IC50 = 230 nM).1 It poorly inhibits phosphioinositide 3 kinase (IC50 = 13 μM) and is inactive against ataxia telangiectasia mutated kinase, ATR, and poly (ADP-ribose) polymerase.1 NU 7026 impairs cellular DNA double strand break repair and decreases survival in cells exposed to ionizing radiation.1 It also potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia. For example, it potentiates the growth inhibitory effects of mitoxantrone in K562 cells more than 10-fold.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Veuger, S.J., Curtin, N.J., Richardson, C.J., et al. Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-1. Cancer Res. 63(18), 6008-6015 (2003).

    2. Willmore, E., de Caux, S., Sunter, N.J., et al. Anovel DNA-dependent protein kinase inhibitor, NU7026, potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia. Blood 103(12), 4659-4665 (2004).