A PKCα/β1 inhibitor
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Gö 6976

Item No. 13310

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5,6,7,13-tetrahydro-13-methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile
CAS Number
136194-77-9
Synonyms
  • PD 406976
Molecular Formula
C24H18N4O
Formula Weight
378.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMF:PBS (pH 7) (1:10): 0.1 mg/mlDMSO: 10 mg/ml
λmax
245, 290, 332, 367 nm
SMILES
O=C1NCC2=C3C(N(CCC#N)C4=CC=CC=C43)=C5C(C6=CC=CC=C6N5C)=C21
InChi Code
InChI=1S/C24H18N4O/c1-27-17-9-4-2-7-14(17)20-21-16(13-26-24(21)29)19-15-8-3-5-10-18(15)28(12-6-11-25)23(19)22(20)27/h2-5,7-10H,6,12-13H2,1H3,(H,26,29)
InChi Key
VWVYILCFSYNJHF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $54

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    1 mg

    $102

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    5 mg

    $238

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    Product Description

    Gö 6976 is a nonglycosidic indolocarbazole that inhibits protein kinase C (PKC) with IC50 values of 2.3 and 6.2 nM for PKCα and PKCβ1, respectively.1 It does not inhibit the activity of PKCδ, PKCε, or PKCζ (IC50s > 3 μM), indicating a preference for the Ca2+-dependent subtypes, PKCα and PKCβ1.1 Gö 6976 also inhibits the checkpoint kinases Chk1/2.2 It was shown to abrogate DNA damage-induced S- and G2-phase cell cycle arrest, leading to cytotoxicity in p53 mutant tumor cells.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Martiny-Baron, G., Kazanietz, M.G., Mischak, H., et al. Selective inhibition of protein kinase C isoenzymes by the indolocarbazole Gö 6976. The Journal of Biological Chemisty 268, 9194-9197 (1993).

    2. Kohn, E.A., Yoo, C.J., and Eastman, A. The protein kinase C inhibitor Gö6976 is a potent inhibitor of DNA damage-induced S and G2 cell cycle checkpoints. Cancer Res. 63, 31-35 (2003).

    3. Kawabe, T. G2 checkpoint abrogators as anticancer drugs. Mol. Cancer Ther. 3(4), 513-519 (2004).