Inhibitor of protein kinase C
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Gö 6983

Item No. 13311

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[1-[3-(dimethylamino)propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione
CAS Number
133053-19-7
Molecular Formula
C26H26N4O3
Formula Weight
442.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMF:PBS (pH 7) (1:10): 0.1 mg/mlDMSO: 10 mg/ml
SMILES
COc1ccc2n(CCCN(C)C)cc(C3=C(C(=O)NC3=O)c3c[nH]c4ccccc34)c2c1
InChi Code
InChI=1S/C26H26N4O3/c1-29(2)11-6-12-30-15-20(18-13-16(33-3)9-10-22(18)30)24-23(25(31)28-26(24)32)19-14-27-21-8-5-4-7-17(19)21/h4-5,7-10,13-15,27H,6,11-12H2,1-3H3,(H,28,31,32)
InChi Key
LLJJDLHGZUOMQP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $54

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    5 mg

    $190

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    10 mg

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    Product Description

    Gö 6983 inhibits several isoforms of protein kinase C (PKC; IC50 = 7, 7, 6, 10, 60, and 20,000 nM for PKCα, PKCβ, PKCγ, PKCδ, PKCζ, and PKCμ, respectively).1 It provides cardioprotective effects in myocardial ischemia/reperfusion by attenuating contractile dysfunction.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gschwendt, M., Dieterich, S., Rennecke, J., et al. Inhibition of protein kinase C μ by various inhibitors. Differentiation from protein kinase c isoenzymes. FEBS Lett. 392, 77-80 (1996).

    2. Peterman, E.E., Taormina, P., II, Harvey, M., et al. Gö 6983 exerts cardioprotective effects in myocardial ischemia/reperfusion. J. Biomed. Sci. 43, 645-656 (2004).

    3. Young, L.H., Balin, B.J., and Weis, M.T. Gö 6983: A fast acting protein kinase C inhibitor that attenuates myocardial ischemia/reperfusion injury. Cardiovasc. Drug Rev. 23(3), 255-272 (2005).

    Product Citations

    Isotani, R., Igarashi, M., Miura, M., et al. Nicotine enhances the stemness and tumorigenicity in intestinal stem cells via Hippo-YAP/TAZ and Notch signal pathway. Elife 13, RP95267 (2025).