An inhibitor of phosphatases
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bpV(phen) (potassium hydrate)

Item No. 13331

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(PB-7-23-111’1’3)-oxodiperoxy(1,10-phenanthroline-κN1,κN10)-vanadate(1-), potassium trihydrate
CAS Number
171202-16-7
Synonyms
  • Bisperoxovanadium(phen)
  • Potassium Bisperoxo(1,10-phenanthroline) oxovanadate (V)
Molecular Formula
C12H8N2O5V • K+(H2O)3
Formula Weight
404.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 1 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
224, 272 nm
SMILES
O=[V+3]12([N]3=CC=C4)([O-][O-]1)([O-][O-]2)[N]5=C6C3=C4C=CC6=CC=C5.O.O.O.[K+]
InChi Code
InChI=1S/C12H8N2.K.2O2.3H2O.O.V/c1-3-9-5-6-10-4-2-8-14-12(10)11(9)13-7-1;;2*1-2;;;;;/h1-8H;;;;3*1H2;;/q;+1;2*-2;;;;;+3
InChi Key
TYPQOCBUPQJDHB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    5 mg

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    Product Description

    bpV(phen) is a bisperoxovanadium (bpV) compound which inhibits several different protein tyrosine phosphatases (PTPs), with selectivity for PTEN (IC50 = 38 nM).1,2 It also inhibits the vascular endothelial PTP, PTP-β (IC50 = 343 nM), and PTP-1β (IC50 = 920 nM).2,3 At 0.1 mM, bpV(phen) inhibits SH2 domain-containing inositol 5’-phosphatase-2.4 Presumably by inhibiting insulin receptor kinase-associated PTPs, bpV(phen) activates the insulin receptor tyrosine kinase and promotes downstream signaling, including activation of PI3-kinase.5,6,7

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lai, J.P., Dalton, J.T., and Knoell, D.L. Phosphatase and tensin homologue deleted on chromosome ten (PTEN) as a molecular target in lung epithelial wound repair. Br. J. Pharmacol. 152(8), 1172-1184 (2007).

    2. Schmid, A.C., Byrne, R.D., Vilar, R., et al. Bisperoxovanadium compounds are potent PTEN inhibitors. FEBS Lett. 566(1-3), 35-38 (2004).

    3. Kakazu, A., Sharma, G., and Bazan, H.E.P. Association of protein tyrosine phosphatases (PTPs)-1B with c-Met receptor and modulation of corneal epithelial wound healing. Invest. Ophthalmol. Vis. Sci. 49(7), 2927-2935 (2008).

    4. Batty, I.H., van der Kaay, J., Gray, A., et al. The control of phosphatidylinositol 3,4-bisphosphate concentrations by activation of the Src homology 2 domain containing inositol polyphosphate 5-phosphatase 2, SHIP2. Biochem J. 407(2), 255-266 (2007).

    5. Posner, B.I., Faure, R., Burgess, J.W., et al. Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics. The Journal of Biological Chemisty 269(6), 4596-4604 (1994).

    6. Bevan, A.P., Burgess, J.W., Drake, P.G., et al. Selective activation of the rat hepatic endosomal insulin receptor kinase. Role for the endosome in insulin signaling. The Journal of Biological Chemisty 270(18), 10784-10791 (1995).

    7. Band, C.J., Posner, B.I., Dumas, V., et al. Early signaling events triggered by peroxovanadium [bpV(phen)] are insulin receptor kinase (IRK)-dependent: Specificity of inhibition of IRK-associated protein tyrosine phosphatase(s) by bpV(phen). Mol. Endocrinol. 11(13), 1899-1910 (1997).