Tyrosine kinase inhibitor
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ST638

Item No. 13337

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-cyano-3-[3-ethoxy-4-hydroxy-5-[(5-phenylthio)methyl]phenyl]-2-propenamide
CAS Number
107761-24-0
Molecular Formula
C19H18N2O3S
Formula Weight
354.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMF:PBS (pH 7.2) (1:9): 0.1 mg/mlDMSO: 30 mg/ml
λmax
252, 363 nm
SMILES
OC1=C(C=C(C=C(C(N)=O)C#N)C=C1OCC)CSC2=CC=CC=C2
InChi Code
InChI=1S/C19H18N2O3S/c1-2-24-17-10-13(8-14(11-20)19(21)23)9-15(18(17)22)12-25-16-6-4-3-5-7-16/h3-10,22H,2,12H2,1H3,(H2,21,23)
InChi Key
YKLMGKWXBLSKPK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $42

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    5 mg

    $183

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    10 mg

    $322

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    25 mg

    $702

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    Product Description

    ST638 is a tyrosine kinase inhibitor (IC50 = 370 nM). It suppresses tyrosine phosphorylation induced by tumor necrosis factor-α and phorbol myristate acetate in neutrophils and by angiotensin II in cardiac fibroblasts.1,2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fuortes, M., Jin, W.W., and Nathan, C. Adhesion-dependent protein tyrosine phosphorylation in neutrophils treated with tumor necrosis factor. J. Cell Biol. 120(3), 777-784 (1993).

    2. Murasawa, S., Mori, Y., Nozawa, Y., et al. Role of calcium-sensitive tyrosine kinase Pyk2/CAKβ/RAFTK in angiotensin II-induced Ras/ERK signaling. Hypertension 32, 668-675 (1998).

    3. Takemasa, H., Imagawa, N., Kawakami-Honda, N., et al. Effect of phosphotyrosine proteins on phorbol myristate acetate-induced NADPH oxidase activation in guinea pig peritoneal polymorphonuclear leukocytes. Biol. Pharm. Bull. 26(7), 1009-1012 (2003).