Inhibitor of Src kinases
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SU6656

Item No. 13338

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,3-dihydro-N,N-dimethyl-2-oxo-3-[(4,5,6,7-tetrahydro-1H-indol-2-yl)methylene]-1H-indole-5-sulfonamide
CAS Number
330161-87-0
Molecular Formula
C19H21N3O3S
Formula Weight
371.5
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/ml
λmax
232, 300, 445 nm
SMILES
O=C(/C1=C\C2=CC3=C(CCCC3)N2)NC4=C1C=C(S(=O)(N(C)C)=O)C=C4
InChi Code
InChI=1S/C19H21N3O3S/c1-22(2)26(24,25)14-7-8-18-15(11-14)16(19(23)21-18)10-13-9-12-5-3-4-6-17(12)20-13/h7-11,20H,3-6H2,1-2H3,(H,21,23)/b16-10-
InChi Key
LOGJQOUIVKBFGH-YBEGLDIGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    The Src family of proto-oncogenic kinases include nine mammalian non-receptor tyrosine kinases that are involved in intracellular signaling and are often relevant to carcinogenesis. SU6656 is a selective inhibitor of Src kinases, Including Src, Yes, Lyn, and Fyn (IC50 = 280, 20, 130, 170 nM, respectively).1 It weakly inhibits some other kinases when used at >10 μM.1,2 SU6656 has been used to study the role of Src kinases in cell growth and development in diverse processes, including nervous system development, fibrosis, and cancer.3,4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Blake, R.A., Broome, M.A., Liu, X., et al. SU6656, a selective Src family kinase inhibitor, used to probe growth factor signaling. Mol. Cell. Biol. 20(23), 9018-9027 (2000).

    2. Bain, J., McLauchlan, H., Elliot, M., et al. The specificities of protein kinase inhibitors: An update. Biochem. J. 371(Pt. 1), 199-204 (2003).

    3. Jin, W., Yun, C., Jeong, J., et al. c-Src is required for tropomyosin receptor kinase C (TrkC)-induced activation of the phosphatidylinositol 3-kinase (PI3K)-AKT pathway. The Journal of Biological Chemisty 283(3), 1391-1400 (2008).

    4. Distler, J.H.W., and Distler, O. Intracellular tyrosine kinases as novel targets for anti-fibrotic therapy in systemic sclerosis. Rheumatology 47(Suppl 5), 10-11 (2008).

    5. Fossey, S.L., Liao, A.T., McCleese, J.K., et al. Characterization of STAT3 activation and expression in canine and human osteosarcoma. BMC Cancer 9:81, (2009).