Selective inhibitor of SPHK1
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CAY10621

Item No. 13371

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(4S)-2,2-dimethyl-4-(1-oxo-2-hexadecyn-1-yl)-3-oxazolidinecarboxylic acid, 1,1-dimethylethyl ester
CAS Number
120005-55-2
Synonyms
  • SKI 5C
  • SPHK1 Inhibitor 5C
Molecular Formula
C26H45NO4
Formula Weight
435.6
Purity
≥98%
Formulation (Request formulation change)
A 10 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: 3 mg/mlDMSO: 2 mg/mlEthanol: 2.5 mg/ml
λmax
224 nm
SMILES
CCCCCCCCCCCCCCCC(=O)[C@@H]1COC(C)(C)N1C(=O)OC(C)(C)C
InChi Code
InChI=1S/C26H45NO4/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-23(28)22-21-30-26(5,6)27(22)24(29)31-25(2,3)4/h22H,7-18,21H2,1-6H3/t22-/m1/s1
InChi Key
YGBSGZPIDCXNEH-JOCHJYFZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $31

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    5 mg

    $129

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    10 mg

    $228

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    25 mg

    $493

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    Product Description

    CAY10621 is an inhibitor of sphingosine kinase 1 (SPHK1; IC50 = 3.3 μM).1 It is selective for SPHK1 over SPHK2 at 10 μM and PKC at concentrations less than 100 μM. CAY10621 inhibits SPHK1 activity by 70% in U937 cells when used at a concentration of 5 μM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wong, L., Tan, S.L., Lam, Y., et al. Synthesis and evaluation of sphingosine analogues as inhibitors of sphingosine kinases. J. Med. Chem. 52, 3618-3626 (2009).

    Product Citations

    Chang, Y.-C., Liu, H.-P., Chuang, H.-L., et al. Feline mammary carcinoma-derived extracellular vesicle promotes liver metastasis via sphingosine kinase-1-mediated premetastatic niche formation. Lab Anim. Res. 39(1), 27 (2023).

    Zhao, C., Amiable, N., Laflamme, M., et al. Impairment of chemical hypoxia-induced sphingosine kinase-1 expression and activation in rheumatoid arthritis synovial fibroblasts: A signature of exhaustion? Biochem. Pharmacol. 165, 249-262 (2019).

    Beach, J.A., Aspuria, P.J., Cheon, D.J., et al. Sphingosine kinase 1 is required for TGF-β mediated fibroblast-to-myofibroblast differentiation in ovarian cancer. Oncotarget 7(4), 4167-4182 (2016).

    Park, S.W., Kim, M., Kim, M., et al. Sphingosine kinase 1 protects against renal ischemia-reperfusion injury in mice by sphingosine-1-phosphate1 receptor activation. Kidney Int. 80(12), 1315-1327 (2011).