A CDK4 and CAMKII inhibitor
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Arcyriaflavin A

Item No. 13516

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
CAS Number
118458-54-1
Molecular Formula
C20H11N3O2
Formula Weight
325.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMF:PBS (pH 7.2) (1:2): 0.33 mg/mlDMSO: 1 mg/ml
λmax
235, 281, 315 nm
SMILES
O=C1NC(C2=C1C(C3=CC=CC=C3N4)=C4C5=C2C6=C(C=CC=C6)N5)=O
InChi Code
InChI=1S/C20H11N3O2/c24-19-15-13-9-5-1-3-7-11(9)21-17(13)18-14(16(15)20(25)23-19)10-6-2-4-8-12(10)22-18/h1-8,21-22H,(H,23,24,25)
InChi Key
KAJXOWFGKYKMMZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $63

    Add

    5 mg

    $153

    Add

    10 mg

    $242

    Add
    Kinase Resource Center
    Discover Products & Resources for Kinase Research
    • Kinase inhibitors, screening libraries, assay kits, & more
    • Tools to study kinase signaling pathways:
      • Growth factor signaling
      • PI3K/Akt/mTOR
      • MAPKs (ERK, p38, & JNK)
      • JAK/STAT signaling
    • Articles, resources, & advice
    EXPLORE NOW
    Product Description

    Arcyriaflavin A is an inhibitor of cyclin-dependent kinase 4 (CDK4; IC50 = 140 nM) and calcium/calmodulin-dependent protein kinase II (CaMKII; IC50 = 25 nM).1 It is selective for CDK4 and CaMKII over protein kinase A (PKA) and PKC (IC50s = >2 and >100 µM, respectively). In vitro, arcyriaflavin A inhibits replication of human cytomegalovirus (HCMV; IC50 = 200 nM), as well as proliferation of HCT116 and NCI H460 human carcinoma cells (IC50s = 850 and 590 nM, respectively).1,2 It also inhibits proliferation and induces apoptosis of endometriotic cyst stromal cells (ECSCs).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sanchez-Martinez, C., Shih, C., Faul, M.M., et al. Aryl[a]pyrrolo[3,4-c]carbazoles as selective cyclin D1-CDK4 inhibitors. Bioorg. Med. Chem. Lett. 13(21), 3835-3839 (2003).

    2. Slater, M.J., Cockerill, S., Baxter, R., et al. Indolocarbazoles: Potent, selective inhibitors of human cytomegalovirus replication. Bioorg. Med. Chem. 7(6), 1067-1074 (1999).

    3. Hirakawa, T., Nasu, K., Aoyagi, Y., et al. Arcyriaflavin a, a cyclin D1-cyclin-dependent kinase4 inhibitor, induces apoptosis and inhibits proliferation of human endometriotic stromal cells: A potential therapeutic agent in endometriosis. Reprod. Biol. Endocrinol. 15(1), 53 (2017).