Amino acid derivative
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Labeled Version(s)
9000372S-Adenosylhomocysteine-d4
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S-Adenosylhomocysteine

Item No. 13603

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
S-(5’-deoxyadenosin-5’-yl)-L-homocysteine
CAS Number
979-92-0
Synonyms
  • AdoHcy
  • SAH
Molecular Formula
C14H20N6O5S
Formula Weight
384.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
1M HCl: 20 mg/ml
λmax
260 nm
SMILES
O[C@@H]1[C@H](O)[C@@H](CSCC[C@H](N)C(O)=O)O[C@H]1N2C(N=CN=C3N)=C3N=C2
InChi Code
InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6?,7-,9-,10-,13-/m1/s1
InChi Key
ZJUKTBDSGOFHSH-ZRURSIFKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    10 mg

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    25 mg

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    50 mg

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    Product Description

    S-Adenosyl-L-homocysteine (SAH) is an amino acid derivative and an intermediate, by-product, or modulator of several metabolic pathways, including the activated methyl cycle and cysteine biosynthesis. It is also a product of S-adenosyl-methionine (SAM)-dependent methylation of biological molecules, including DNA, RNA, and histones and other proteins. SAH is a risk factor for many diseases, including cancer and neurodegenerative diseases. In addition, inhibitors that block its hydrolysis are being developed as anti-viral, anti-parasitic, anti-arthritic and immunosuppressive agents.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Citations

    Coussens, N.P., Kales, S.C., Henderson, M.J., et al. High-throughput screening with nucleosome substrate identifies small-molecule inhibitors of the human histone lysine methyltransferase NSD2. The Journal of Biological Chemisty 293(35), 13750-13765 (2018).