An internal standard for the quantification of 13,14-dihydro-15-keto prostaglandin E1
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Unlabeled Version(s)
1365013,14-dihydro-15-keto Prostaglandin E1
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13,14-dihydro-15-keto Prostaglandin E1-d4

Item No. 9000288

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9,15-dioxo-11α-hydroxy-prostan-1-oic-3,3,4,4-d4 acid
Synonyms
  • 13,14-dh-15-k PGE1-d4
Molecular Formula
C20H30O5D4
Formula Weight
358.5
Purity
≥99% deuterated forms (d1-d4)
Formulation
A 100 µg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 50 mg/mlEthanol: 50 mg/mlPBS: 1 mg/ml
SMILES
CCCCCC(CC[C@H]([C@H]1CCCC([2H])([2H])C([2H])([2H])CC(O)=O)[C@H](O)CC1=O)=O
InChi Code
InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h16-17,19,23H,2-14H2,1H3,(H,24,25)/t16-,17-,19-/m1/s1/i5D2,8D2
InChi Key
CDUVSQMTLOYKTR-GBXRSTSUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    25 µg

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    100 µg

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    Product Description

    13,14-dihydro-15-keto Prostaglandin E1-d4 (13,14-dh-15-k PGE1-d4) is intended for use as an internal standard for the quantification of 13,14-dh-15-k PGE1 by GC- or LC-mass spectrometry. 13,14-dh-15-k PGE1 is a metabolite of PGE1 with much reduced biological activity.1,2,3 Steady state plasma concentrations are about 10 pg/ml.1 13,14-dh-15-k PGE1 is a weak inhibitor of ADP-induced platelet aggregation in human PRP and washed platelets with IC50 values of 54 and 200 µM, respectively, compared to PGE1 which has an IC50 value of 40 nM.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Leonhardt, A., Krauss, M., Gieler, U., et al. In vivo formation of prostaglandin E1 and prostaglandin E2 in atopic dermatitis. Br. J. Dermatol. 136(3), 337-340 (1997).

    2. Hamberg, M., and Samuelsson, B. On the metabolism of prostaglandins E1 and E2 in man. The Journal of Biological Chemisty 246(22), 6713-6721 (1971).

    3. Peskar, B.A., Cawello, W., Rogatti, W., et al. On the metabolism of prostaglandin E1 administered intravenously to human volunteers. J. Physiol. Pharmacol. 42(3), 327-331 (1991).

    4. Kobzar, G., Mardla, V., Järving, I., et al. Antiaggregating potency of E-type prostaglandins in human and rabbit platelets. Proc. Estonian Acad. Sci. Chem. 40(N3), 179-180 (1991).