An HDAC inhibitor
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Chidamide

Item No. 13686

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(2-amino-4-fluorophenyl)-4-[[[(2E)-1-oxo-3-(3-pyridinyl)-2-propen-1-yl]amino]methyl]-benzamide
CAS Number
1616493-44-7
Synonyms
  • CS 055
  • HBI 8000
  • Tucidinostat
Molecular Formula
C22H19FN4O2
Formula Weight
390.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlDMSO:PBS(pH7.2) (1:1): 0.5 mg/ml
λmax
203, 238, 258 nm
SMILES
FC1=CC(N)=C(NC(C2=CC=C(CNC(/C=C/C3=CC=CN=C3)=O)C=C2)=O)C=C1
InChi Code
InChI=1S/C22H19FN4O2/c23-18-8-9-20(19(24)12-18)27-22(29)17-6-3-16(4-7-17)14-26-21(28)10-5-15-2-1-11-25-13-15/h1-13H,14,24H2,(H,26,28)(H,27,29)/b10-5+
InChi Key
SZMJVTADHFNAIS-BJMVGYQFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    10 mg

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    25 mg

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    Cayman Chemical
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    Product Description

    Chidamide is an inhibitor of histone deacetylases (HDACs; IC50s = 0.095, 0.160, 0.067, 0.733, 0.078, and 0.432 µM for HDAC1-3, 8, 10, and 11, respectively).1 It is selective for these HDACs over HDAC4-7 and 9 (IC50s = >30 µM for all). Chidamide also inhibits nicotinamide phosphoribosyltransferase (Nampt; IC50 = 2.1 µM).2 It inhibits cell growth in a panel of 18 cancer cell lines (GI50s = 0.4-40 µM) but has no effect on the growth of non-cancerous CCC-HEK human fetal kidney or CCC-HEL human liver cells (GI50s = >100 µM).1 In vivo, tucidinostat (12.5, 25, and 50 mg/kg) reduces tumor growth in HCT-8, A549, BEL-7402, and MCF-7 mouse xenograft models.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ning, Z.-Q., Li, Z.-B., Newman, M.J., et al. Chidamide (CS055/HBI-8000): A new histone deacetylase inhibitor of the benzamide class with antitumor activity and the ability to enhance immune cell-mediated tumor cell cytotoxicity. Cancer Chemother. Pharmacol. 69(4), 901-909 (2012).

    2. Wu, Y., Wang, L., Huang, Y., et al. Nicotinamide phosphoribosyltransferase (NAMPT) is a new target of antitumor agent chidamide. ACS Med. Chem. Lett. 11(1), 40-44 (2020).