Inhibitor of γ-glutamyl transferase
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OU749

Item No. 13804

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[5-[(4-methoxyphenyl)methyl]-1,3,4-thiadiazol-2-yl]-benzenesulfonamide
CAS Number
519170-13-9
Molecular Formula
C16H15N3O3S2
Formula Weight
361.4
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mlEthanol: 5 mg/ml
λmax
203, 223, 274 nm
SMILES
COC1=CC=C(CC2=NN=C(NS(C3=CC=CC=C3)(=O)=O)S2)C=C1
InChi Code
InChI=1S/C16H15N3O3S2/c1-22-13-9-7-12(8-10-13)11-15-17-18-16(23-15)19-24(20,21)14-5-3-2-4-6-14/h2-10H,11H2,1H3,(H,18,19)
InChi Key
QCXWBMZVLJCKHF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    10 mg

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    25 mg

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    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

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    OBESITY RESEARCH SOLUTIONS
    Product Description

    γ-Glutamyl transferase (GGT) is involved in the transfer of amino acids across the plasma membrane as well as in glutathione metabolism.1 Serum GGT activity is commonly used as a marker of liver dysfunction and alcohol abuse. It is also useful as a biomarker of type 2 diabetes and cardiovascular disease.1 OU749 is a non-competitive inhibitor of GGT, exhibiting a Ki value of 17.6 μM.2 It is 150-fold less toxic than the GGT inhibitor acivicin toward dividing cells. OU749 inhibits human GGT 7- to 10-fold more potently than rat or murine GGT and does not inhibit porcine GGT.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Targher, G. Elevated serum γ-glutamyltransferase activity is associated with increased risk of mortality, incident type 2 diabetes, cardiovascular events, chronic kidney disease and cancer - a narrative review. Clin. Chem. Lab. Med. 48(2), 147-157 (2010).

    2. King, J.B., West, M.B., Cook, P.F., et al. A novel, species-specific class of uncompetitive inhibitors of γ-glutamyl transpeptidase. The Journal of Biological Chemisty 284(14), 9059-9065 (2009).

    Product Citations

    Hayashima, K., and Katoh, H. Expression of gamma-glutamyltransferase 1 in glioblastoma cells confers resistance to cystine deprivation-induced ferroptosis. The Journal of Biological Chemisty 298(3), 101703 (2022).