A HDAC inhibitor
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Pyroxamide

Item No. 13870

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N1-hydroxy-N8-3-pyridinyl-octanediamide
CAS Number
382180-17-8
Molecular Formula
C13H19N3O3
Formula Weight
265.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 5 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
λmax
203, 241, 279 nm
SMILES
O=C(CCCCCCC(NO)=O)NC1=CC=CN=C1
InChi Code
InChI=1S/C13H19N3O3/c17-12(15-11-6-5-9-14-10-11)7-3-1-2-4-8-13(18)16-19/h5-6,9-10,19H,1-4,7-8H2,(H,15,17)(H,16,18)
InChi Key
PTJGLFIIZFVFJV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $68

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    10 mg

    $118

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    25 mg

    $275

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    50 mg

    $451

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    Cayman Chemical
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    Product Description

    Pyroxamide is an inhibitor of histone deacetylases (HDACs), including HDAC1 (IC50 = 0.1-0.2 μM).1,2 It induces growth suppression and cell death of certain types of cancer cells in culture.3,1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Butler, L.M., Webb, Y., Agus, D.B., et al. Inhibition of transformed cell growth and induction of cellular differentiation by pyroxamide, an inhibitor of histone deacetylase. Clin. Cancer Res. 7, 962-970 (2001).

    2. Remiszewski, S.W., Sambucetti, L.C., Atadja, P., et al. Inhibitors of human histone deacetylase: Synthesis and enzyme and cellular activity of straight chain hydroxamates. J. Med. Chem. 45(4), 753-757 (2002).

    3. Kutko, M.C., Glick, R.D., Butler, L.M., et al. Histone deacetylase inhibitors induce growth suppression and cell death in human rhabdomyosarcoma in vitro. Clin. Cancer Res. 9, 5749-5755 (2003).