A cell permeable inhibitor of PRMTs
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AMI-1 (sodium salt)

Item No. 13965

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7,7'-(carbonylbis(azanediyl))bis(4-oxidonaphthalene-2-sulfonate), sodium salt
Synonyms
  • Arginine N-Methyltransferase Inhibitor-1
Molecular Formula
C21H12N2O9S2 • 4Na
Formula Weight
592.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Water: 10 mg/ml
SMILES
O=C(NC1=CC(C=C(S(=O)([O-])=O)C=C2[O-])=C2C=C1)NC3=CC4=C(C([O-])=CC(S(=O)([O-])=O)=C4)C=C3.[Na+].[Na+].[Na+].[Na+]
InChi Code
InChI=1S/C21H16N2O9S2.4Na/c24-19-9-15(33(27,28)29)7-11-5-13(1-3-17(11)19)22-21(26)23-14-2-4-18-12(6-14)8-16(10-20(18)25)34(30,31)32;;;;/h1-10,24-25H,(H2,22,23,26)(H,27,28,29)(H,30,31,32);;;;/q;4*+1/p-4
InChi Key
OEJIOAHFKHHDAW-UHFFFAOYSA-J
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    5 mg

    $103

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    25 mg

    $423

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    Cayman Chemical
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    Product Description

    AMI-1 is a cell permeable inhibitor of PRMTs. It inhibits both yeast Type I arginine methyltransferase Hmt1p and human PRMT1 (IC50 = 3.0 and 8.8 μM, respectively).1 AMI-1 also effectively blocks the activity of PRMTs 3, 4, and 6 but not that of either SET (Sub39H1, Suv39H2, SET7) or non-SET (DOT1) lysine methyltransferases.1 The mechanism of inhibition of PRMTs by AMI-1 involves blocking peptide-substrate binding.2 AMI-1 also inhibits HIV-1 reverse transcriptase (IC50 = 5.0 μM).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cheng, D., Yadav, N., King, R.W., et al. Small molecule regulators of protein arginine methyltransferases. The Journal of Biological Chemisty 279(23), 23892-23899 (2004).

    2. Feng, Y., Xie, N., Wu, J., et al. Inhibitory study of protein arginine methyltransferase 1 using a fluorescent approach. Biochem. Biophys. Res. Commun. 379(2), 567-572 (2009).

    3. Skillman, A.G., Maurer, K.W., Roe, D.C., et al. A novel mechanism for inhibition of HIV-1 reverse transcriptase. Bioorg. Chem. 30(6), 443-458 (2002).