An agonist of GPR139
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TC-O 9311

Item No. 14030

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,5-dimethoxy-benzoic acid, 2-[(1-naphthalenylamino)carbonyl]hydrazide
CAS Number
444932-31-4
Molecular Formula
C20H19N3O4
Formula Weight
365.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 14mg/mLDMSO: 11mg/mLEthanol: 14mg/mLPBS (pH 7.2): 5mg/mL
λmax
221, 293 nm
SMILES
COC1=CC(OC)=CC(C(NNC(NC2=CC=CC3=C2C=CC=C3)=O)=O)=C1
InChi Code
InChI=1S/C20H19N3O4/c1-26-15-10-14(11-16(12-15)27-2)19(24)22-23-20(25)21-18-9-5-7-13-6-3-4-8-17(13)18/h3-12H,1-2H3,(H,22,24)(H2,21,23,25)
InChi Key
KPTMSQHTGZMEFU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $36

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    5 mg

    $128

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    10 mg

    $203

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    25 mg

    $462

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    Product Description

    TC-O 9311 is an agonist of the orphan G protein-coupled receptor GPR139 (EC50 = 39 nM in a calcium mobilization assay).1 It is selective for GPR139 over a panel of 90 additional targets. TC-O 9311 (1 μM) inhibits cell death induced by 1-methyl-4-phenylpyridinium (MPP+), but not 6-hydroxydopamine (6-OHDA; Item No. 25330), in primary dopaminergic midbrain neurons.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shi, F., Shen, J.K., Chen, D., et al. Discovery and SAR of a series of agonists at orphan G protein-coupled receptor 139. ACS Med. Chem. Lett. 2(4), 303-306 (2011).

    2. Bayer Andersen, K., Leander Johansen, J., Hentzer, M., et al. Protection of primary dopaminergic midbrain neurons by GPR139 agonists supports different mechanisms of MPP+ and rotenone toxicity. Front. Cell. Neurosci. 10:164, (2016).