An Analytical Reference Standard
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Active Metabolite(s)
29469(−)-11-hydroxy-Δ8-THC 420228β,9β-epoxy Hexahydrocannabinol 446088β,9β-epoxy Hexahydrocannabinol (exempt preparation)
Certified Reference Material(s)
41193Δ8-THC (Alt. Batch CRM) ISO60158Δ8-THC (CRM)
Isomer(s)
9003416(+)-Cannabidiol 38947(+)-cis-Cannabidiol 35329(+)-Δ8-THC 33453(+)-Δ9-THC 34628(+)-Δ9-THC (exempt preparation) 26252(±)-Cannabichromene 41376(±)-Cannabichromene (Alt. Batch CRM) ISO60163(±)-Cannabichromene (CRM) 9002438(±)-Cannabicyclol42627(±)-Cannabicyclol (Alt. Batch CRM) 9003741(±)-Cannabidiol 27074(±)-cis-Δ9-THC 42464(±)-cis-Δ9-THC (CRM) 9003740(±)-Δ9-THC 34629(±)-Δ9-THC (exempt preparation) 41814(6aR,9R)-Δ10-THC (Alt. Batch CRM) 42625(6aR,9S)-Δ10-THC (Alt. Batch CRM) 37046(9,10a)-anti-Δ6a,7-THC 41297(9,10a)-anti-Δ6a,7-THC (exempt preparation) 37047(9,10a)-syn-Δ6a,7-THC 426299(R)-Δ6a,10a-THC (Alt. Batch CRM) 330139(R)-Δ6a,10a-THC (CRM) 340769(R)-Δ7-THC 391879(R)-Δ7-THC (CRM) 421419(S)-Δ6a,10a-THC (Alt. Batch CRM) 330149(S)-Δ6a,10a-THC (CRM) 340779(S)-Δ7-THC 393179(S)-Δ7-THC (CRM) 10004259Abnormal Cannabidiol 90080Cannabidiol 41217Cannabidiol (Alt. Batch CRM) 41216exo-THC (Alt. Batch CRM) 36898exo-THC (CRM) 33863Δ4(8)-iso-THC 39955Δ4(8)-iso-THC (CRM) 43198Δ8-cis-iso-THC 33864Δ8-iso-THC 39000Δ8-iso-THC (CRM) 12068Δ9-THC 42138Δ9-THC (Alt. Batch CRM) ISO60157Δ9-THC (CRM) 43003Δ9-THC (CRM) 45655Δ9-THC (CRM) 9003771Δ9-THC (solution)
Labeled Version(s)
16205Δ8-THC-d9 41379Δ8-THC-d9 (CRM) 45549Δ8-THC-d9 (CRM)
Metabolite(s)
34023(−)-11-hydroxy-Δ8-THC (CRM) 25270(−)-11-nor-9-carboxy-Δ8-THC 34024(−)-11-nor-9-carboxy-Δ8-THC (CRM) 420218α,9α-epoxy Hexahydrocannabinol 446098α,9α-epoxy Hexahydrocannabinol (exempt preparation) 446938α,9α-epoxy Hexahydrocannabinol (exempt preparation) 446948β,9β-epoxy Hexahydrocannabinol (exempt preparation) 38961Δ8-THC Glucuronide
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Δ8-THC

Item No. 14042

Restricted Product (Schedule I)
Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • NSC 134453
  • Δ8-Tetrahydrocannabinol
Technical Information
Formal Name
6aR,7,10,10aR-tetrahydro-6,6,9-trimethyl-3-pentyl-6H-dibenzo[b,d]pyran-1-ol
CAS Number
5957-75-5
Molecular Formula
C21H30O2
Formula Weight
314.5
Purity
≥95%
Formulation
A 50 mg/ml solution in methanol
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMF:PBS (pH 7.2)(1:3): 250 µg/mlDMSO: 60 mg/mlEthanol: 35 mg/mlMethanol: 30 mg/ml
SMILES
CC1=CC[C@](C(C)(C)OC2=C3C(O)=CC(CCCCC)=C2)([H])[C@@]3([H])C1
InChi Code
InChI=1S/C21H30O2/c1-5-6-7-8-15-12-18(22)20-16-11-14(2)9-10-17(16)21(3,4)23-19(20)13-15/h9,12-13,16-17,22H,5-8,10-11H2,1-4H3/t16-,17-/m1/s1
InChi Key
HCAWPGARWVBULJ-IAGOWNOFSA-N
Origin
Synthetic
Regulatory Information
DEA Schedule
I
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Δ8-THC (Item No. 14042) is an analytical reference standard categorized as a phytocannabinoid.1 Δ8-THC is regulated as a Schedule I compound in the United States. This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Krishnamurthy, M., Ferreira, A.M., and Moore, B.M., II Synthesis and testing of novel phenyl substituted side-chain analogues of classical cannabinoids. Bioorg. Med. Chem. Lett. 13(20), 3487-3490 (2003).

    Product Citations

    Schirmer, W., Walton, S.E., Weinmann, W., et al. Rapid LC-QTOF-MS screening method for semi-synthetic cannabinoids in whole blood. J. Anal. Toxicol. bkaf095 (2025).

    Janssens, L.K., Van Uytfanghe, K., Williams, J.B., et al. Investigation of the intrinsic cannabinoid activity of hemp-derived and semisynthetic cannabinoids with β-arrestin2 recruitment assays—and how this matters for the harm potential of seized drugs. Arch. Toxicol. (2024).

    Thapa, D., Cairns, E.A., Szczesniak, A.-M., et al. The cannabinoids D8THC, CBD, and HU-308 act via distinct receptors to reduce corneal pain and inflammation. Cannabis Cannabinoid Res. 3.1, (2018).

    Merrick, J., Lane, B., Sebree, T., et al. Identification of psychoactive degradants of cannabidiol in simulated gastric and physiological fluid. Cannabis Cannabinoid Res. 1.1, 102-112 (2016).