A phospholipid
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Cardiolipin (18:1/18:1/18:1/18:1) (sodium salt)

Item No. 14045

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9-octadecenoic acid (9Z)-(2R,14R)-5,8,11-trihydroxy-5,11-dioxido-4,6,10,12-tetraoxa-5,11-diphosphapentadecane-1,2,14,15-tetrayl ester, disodium salt
CAS Number
115404-77-8
Synonyms
  • 18:1 Cardiolipin
  • 72:4-CL
  • Diphosphatidylglycerol (18:1)
  • Tetraoleoyl Cardiolipin
Molecular Formula
C81H148O17P2 • 2Na
Formula Weight
1502.0
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: Soluble
SMILES
O=C(CCCCCCC/C=C\CCCCCCCC)OC[C@@H](OC(CCCCCCC/C=C\CCCCCCCC)=O)COP([O-])(OCC(COP(OC[C@H](OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O)([O-])=O)O)=O.[Na+].[Na+]
InChi Code
InChI=1S/C81H150O17P2.2Na/c1-5-9-13-17-21-25-29-33-37-41-45-49-53-57-61-65-78(83)91-71-76(97-80(85)67-63-59-55-51-47-43-39-35-31-27-23-19-15-11-7-3)73-95-99(87,88)93-69-75(82)70-94-100(89,90)96-74-77(98-81(86)68-64-60-56-52-48-44-40-36-32-28-24-20-16
InChi Key
HRSSZYQZKAQQME-VXEUWOLISA-L
Side Chain Carbon Sum
72:4
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $61

    Add

    10 mg

    $85

    Add

    25 mg

    $137

    Add
    Cayman Chemical
    Learn More About Leveraging Helper Lipids to Achieve Versatile LNPs
    READ THE ARTICLE
    Product Description

    Cardiolipin (18:1/18:1/18:1/18:1) is an anionic phospholipid containing the monounsaturated fatty acid oleic acid (Item Nos. 90260 | 24659). It has been used in the generation of lipid nanoparticles (LNPs).1 LNPs containing cardiolipin (18:1/18:1/18:1/18:1), 4A3-SCB, DMG-PEG(2000) (Item No. 33945), 1,2-dioleoyl-sn-glycero-3-PE (1,2-DOPE; Item No. 15091), and cholesterol (Item Nos. 9003100 | 39088) and encapsulating mRNA accumulate in the spleen in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Álvarez-Benedicto, E., Farbiak, L., Ramírez, M.M., et al. Optimization of phospholipid chemistry for improved lipid nanoparticle (LNP) delivery of messenger RNA (mRNA). Biomater. Sci. 10(2), 549-559 (2022).