A fluorescent probe for direct detection of peroxynitrite
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Coumarin Boronic Acid

Item No. 14051

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
B-(2-oxo-2H-1-benzopyran-7-yl)-boronic acid
CAS Number
1357078-03-5
Synonyms
  • CBA
Molecular Formula
C9H7BO4
Formula Weight
190.0
Purity
≥98%
Emission
470 nm
Excitation
332 nm
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 11 mg/mlDMSO: 3 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mlEthanol: 1 mg/ml
λmax
280, 320 nm
SMILES
O=C1OC2=CC(B(O)O)=CC=C2C=C1
InChi Code
InChI=1S/C9H7BO4/c11-9-4-2-6-1-3-7(10(12)13)5-8(6)14-9/h1-5,12-13H
InChi Key
MUZVCJQIBNTECF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    10 mg

    $136

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    50 mg

    $643

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    100 mg

    $1,083

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    Product Description

    Coumarin boronic acid (CBA) is a fluorescent probe that can be used to detect peroxynitrite (Item No. 81565), hypochlorous acid, and hydrogen peroxide.1,2,3It reacts with peroxynitrite at an exponentially faster rate (k = 1.1 μM/s) than hydrogen peroxide (k =1.5 M/s) and moderately faster rate than hypochlorous acid.1,2 Peroxynitrite oxidizes CBA into the fluorescent product 7-hydroxycoumarin (COH), which displays excitation/emission maxima of 332/470 nm, respectively.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zielonka, J., Sikora, A., Hardy, M., et al. Boronate probes as diagnostic tools for real time monitoring of peroxynitrite and hydroperoxides. Chem. Res. Toxicol. 25(9), 1793-1799 (2012).

    2. Zielonka, J., Zielonka, M., Sikora, A., et al. Global profiling of reactive oxygen and nitrogen species in biological systems. The Journal of Biological Chemisty 287(5), 2984-2995 (2012).

    3. Zielonka, J., Sikora, J., Joseph, J., et al. Peroxynitrite is the major species formed from different flux ratios of co-generated nitric oxide and superoxide. The Journal of Biological Chemisty 285(19), 14210-14216 (2010).