An antithyroid agent
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Labeled Version(s)
30743Propylthiouracil-d5
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Propylthiouracil

Item No. 14069

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,3-dihydro-6-propyl-2-thioxo-4(1H)-pyrimidinone
CAS Number
51-52-5
Synonyms
  • NSC 6498
  • NSC 70461
  • 6-n-Propylthiouracil
  • PTU
Molecular Formula
C7H10N2OS
Formula Weight
170.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 12.5 mg/mlDMF:PBS (pH 7.2) (1:5): 0.50 mg/mlDMSO: 10 mg/mlEthanol: 2 mg/ml
λmax
214, 275 nm
SMILES
S=C1NC(C=C(CCC)N1)=O
InChi Code
InChI=1S/C7H10N2OS/c1-2-3-5-4-6(10)9-7(11)8-5/h4H,2-3H2,1H3,(H2,8,9,10,11)
InChi Key
KNAHARQHSZJURB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 g

    $36

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    25 g

    $68

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    50 g

    $123

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    100 g

    $215

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    Product Description

    Propylthiouracil (PTU) is a thioamide antithyroid agent.1 It inhibits thyroid peroxidase activity in rat and monkey thyroid microsomes (IC50s = 0.081 and 4.1 μM, respectively). PTU (30 mg/kg) increases thyroid weight and serum thyroid stimulating hormone levels and decreases serum 3,5,3'-triiodothyronine and thyroxine levels in rats. Sensitivity to the bitter taste of PTU is genetically mediated and is associated with increased sensitivity to other sweet and bitter compounds.2 Formulations containing propylthiouracil have been used in the treatment of Graves' disease and hyperthyroidism.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Takayama, S., Aihara, K., Onodera, T., et al. Antithyroid effects of propylthiourad and sulfamonomethoxine in rats and monkeys. Toxicol. Appl. Pharmacol. 82(2), 191-199 (1986).

    2. Drewnowski, A., and Rock, C.L. The influence of genetic taste markers on food acceptance. Am. J. Clin. Nutr. 62(3), 506-511 (1995).